ID Q4DJR9_TRYCC Unreviewed; 895 AA.
AC Q4DJR9;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN92772.1};
GN ORFNames=Tc00.1047053510715.90 {ECO:0000313|EMBL:EAN92772.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN92772.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN92772.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN92772.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN92772.1}.
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DR EMBL; AAHK01000403; EAN92772.1; -; Genomic_DNA.
DR RefSeq; XP_814623.1; XM_809530.1.
DR AlphaFoldDB; Q4DJR9; -.
DR SMR; Q4DJR9; -.
DR PaxDb; 353153-Q4DJR9; -.
DR EnsemblProtists; EAN92772; EAN92772; Tc00.1047053510715.90.
DR GeneID; 3546202; -.
DR KEGG; tcr:510715.90; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4DJR9; -.
DR OrthoDB; 2732516at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 98..464
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 95416 MW; 405C09AEF94269C7 CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGRRREGG ESEPQRPNMS RRVFTSVLLL LFVVMMCCGT
GAATADVGAA EAKGFSPEKP FHWRDVKKDG GTVSSLRAPV LVEVNGGVFA VVEAQCKKGE
KRFTGIASKL LTLTDETLKE DLDATQLKTQ LLVECSSDDV KPGCRVAVQE SGSPNEQIVD
VGRPTTVVEG NDIYMLVGKH SHENLAECKA TSEKFKSGML LVKGEVSGEG GNKQIHWNDT
HGVPCTLGDH QNSLKRLIGG GGSGLKMKDD TILFPVEGTK KEGDAEEDGK TVSLIIYSSS
TSESWKLSNE VPADGCSDPS VVEWEKDKKL MMMTAFGDGR RRVYESGDKG ESWTEALGTL
SRVWGNKHGE KAKGVRSGFI TAKIDGVDDK RNVMLVTLPV YSKEADTGGA QKGKLHLWLT
DNTHIVDIGP VSGEGDEEDV AASSLLYRSG KDGKNKQELI ALYEKKGDEK ETSTGMVSVL
LTAQLERVKE VLTTWNEVDK RVSQLCPSES DVETISPGNA CSPTVKITDG LVGFLSGNLS
DGTWKDEYLG VNATVKGNDG GNKATLHASG VKFQGAWAEW PVGKQGENQL YHFANYNFTL
VATVSIHGEP RGDTSIPLMG AKMNDSGKTV LLGLSYNGGG KWELSCGGGK TEEHSSDWET
EKSEHVVILL RNGNQSSAYV DGKLVGSAEC ECENTKDKEI SHFYIGGDGG SAEGQEGESV
TVTNVLLYNR PWTEEEVGAL NPNKVPITSP VTENMPDTML QSSAKPQPSE QETLTTNIGG
VGGVLSRAAS TATTPSSDFA QEAATRSGDT MLGNGSPQTP EVGVSSGANE ETTEGRDGQK
EGIHAQHGEV NATALSRSLG NVSQGNNSDA GTVRGSGLLP SLLLLLLGLW VFAAL
//
