ID Q4DLE4_TRYCC Unreviewed; 679 AA.
AC Q4DLE4;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN93346.1};
DE Flags: Fragment;
GN ORFNames=Tc00.1047053511311.7 {ECO:0000313|EMBL:EAN93346.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN93346.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN93346.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN93346.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN93346.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01000355; EAN93346.1; -; Genomic_DNA.
DR RefSeq; XP_815197.1; XM_810104.1.
DR AlphaFoldDB; Q4DLE4; -.
DR SMR; Q4DLE4; -.
DR PaxDb; 353153-Q4DLE4; -.
DR EnsemblProtists; EAN93346; EAN93346; Tc00.1047053511311.7.
DR GeneID; 3546886; -.
DR KEGG; tcr:511311.7; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4DLE4; -.
DR OrthoDB; 132144at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 111..449
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 679
FT /evidence="ECO:0000313|EMBL:EAN93346.1"
SQ SEQUENCE 679 AA; 73896 MW; 8E57181F5F12B391 CRC64;
MLSRGAAVKT PRTHNRRGMT GSRGRRREGR ESEPQRPNMS RHLFFSAALL LVVMMCCGTC
GAAAAGGNNG KSDLRNFRKL QRVDLFVPQK TQVLPKGTTS PQTKLDSFVS PSLVSAGGVI
AAFAEGHTNA KVHTNAPKDG VKLITPFYSD VVAGYIDSAW NWTTLVDKVN QSSWRAHIVL
TAADGKKLLG GVHRPTTTTK GNKVFLLGGV EFFNDPESMI WDSLHLKLVV GTVTNSTGGK
PSERISWDDP KSLSVLNTSA ASYEGKFERV FPSGGSGVLM EGGTLVFPVF AFDDNDDYSM
IIYSTDSGAN WMLSNGTSPA KCSNPRITEW EGSLLMIVDC EDGQRVYESR DMGTTWTGTI
GTLPGVWTKS KSAVILDLSL HVDALITATI EEKKVMLYTQ KGYVSGEKRE RALYLWVTDN
NRSFYVGPVA MEDDVSWELA STLLYSDGSL HLLQRRGDYE GSVMSLSRLT EELGTIKSVL
STWAKKDAFF SNLTIPTAGL VAVLSDTASN GTWIDEYLCL NATVTKGRKA KYGFQLTEPS
SRVSWSVNTR GDSIRHVSLS HNFTLVALVT IEEAPSGNTP LLTATLGDTN SNHTMGLSYT
ADKTWGTGLK GKTTKQSGRW EPKKGYQVAL MLQGKKASVY VDGESLGEEE LPLKGERPLE
LVRFCFGACG EDAGQKTNV
//
