ID Q4DMW3_TRYCC Unreviewed; 989 AA.
AC Q4DMW3;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=CNH domain-containing protein {ECO:0000259|PROSITE:PS50219};
GN ORFNames=Tc00.1047053508593.50 {ECO:0000313|EMBL:EAN93859.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN93859.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN93859.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN93859.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN93859.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01000319; EAN93859.1; -; Genomic_DNA.
DR RefSeq; XP_815710.1; XM_810617.1.
DR AlphaFoldDB; Q4DMW3; -.
DR STRING; 353153.Q4DMW3; -.
DR PaxDb; 353153-Q4DMW3; -.
DR EnsemblProtists; EAN93859; EAN93859; Tc00.1047053508593.50.
DR GeneID; 3547474; -.
DR KEGG; tcr:508593.50; -.
DR eggNOG; KOG2063; Eukaryota.
DR InParanoid; Q4DMW3; -.
DR OMA; DETEMAR; -.
DR OrthoDB; 170326at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR032914; Vam6/VPS39/TRAP1.
DR InterPro; IPR019452; VPS39/TGF_beta_rcpt-assoc_1.
DR InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR PANTHER; PTHR12894; CNH DOMAIN CONTAINING; 1.
DR PANTHER; PTHR12894:SF27; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF10366; Vps39_1; 1.
DR Pfam; PF10367; Vps39_2; 1.
DR PROSITE; PS50219; CNH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 16..301
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
SQ SEQUENCE 989 AA; 112098 MW; 2E29796818FAD520 CRC64;
MSHEVFCLRE LKQKLSCKID SIATARNLFF LGTSDGKVMV YEVSLQNRDA QCVYIHNSKH
KLPIRMIIPI VEKGILLVLA GDVIAVHQLS HITHAPLDSL PEDRLPEMNT VKGTKDIVTL
HVKRQRGIFS MAVLQRKKIT LYEYRDHLSE FVMVNDGFLL PDGAKTLLWV GKNIILGFRR
EYVIMNVLSG ATDYLYPTGK SGIPLLLSLD PVPEVLVGDE NKGMRALHDG SLVPGRSGMS
WSSIPTNATY IHPFLLTVHD NNCMEVRLPF FTAHAEASDL SPWQTLSLKG ADRISQRPFA
DFDASLPKEA TPSDALRKDI SILVSSNNTV YLLELLPVRE QVLALASLNC VEAGLILCQL
CANEVDQATV DSLKTQFALW SFHAKKDFKT AMLRFRDANV DPRLVIDLFP GFLTKRARET
WHPPKEYTRS LDTTDLAMDM RSAITAFLDY ALPLRREYAT EEKTVLAEAI DTAIMKAYVV
MGQEQQLLSF LAEENFCSLA ESEVFLVDSE QWVALITLWY FYKQNHKSLA LLYTLGTTRE
RVLLESLLTT SFSRGNLPFD TEFLHILHLL LANSLGKSSS NRVLSDRRDR RANFIPQSVM
MRILDEIAVN ADPSHQLGLL RRCVSVVTTI TYISLLSWDE QEERALVEQY SRWILANVSP
RWSVKMFPVT EIQPKHYTTV LRLLSSDMGD MGDTQPHERR AEWLSLVFDN ACNVKIDASI
HDAYFQSLVH LLLSTFSQEG DGDNNEEKKE RSRISELHQR LENFLRLSEH IDISNARKLL
EQPNLRSHMY AERAIIYRRL ELHEEAICMF LYEAKELQAA QEYAKHVGHD GQDAFQVLLR
LLLHPSDGCT SARLDDVIEM LNTCEGVNLL TALPMLPDDT PILPIAGFIK RSIRDASTRS
RSAAMNASIL EARIRQAELK IALERSRQVV MDLGTCCAVC EKKLRPDVVF ARFPNGVVVH
QACMEDEHIC PITYKDFRLG IEPFARGAL
//
