ID Q4DQ37_TRYCC Unreviewed; 1262 AA.
AC Q4DQ37;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=Tc00.1047053511825.180 {ECO:0000313|EMBL:EAN94644.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN94644.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN94644.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN94644.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN94644.1}.
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DR EMBL; AAHK01000262; EAN94644.1; -; Genomic_DNA.
DR RefSeq; XP_816495.1; XM_811402.1.
DR AlphaFoldDB; Q4DQ37; -.
DR SMR; Q4DQ37; -.
DR STRING; 353153.Q4DQ37; -.
DR PaxDb; 353153-Q4DQ37; -.
DR EnsemblProtists; EAN94644; EAN94644; Tc00.1047053511825.180.
DR GeneID; 3548393; -.
DR KEGG; tcr:511825.180; -.
DR eggNOG; KOG0920; Eukaryota.
DR InParanoid; Q4DQ37; -.
DR OMA; ACFGVLD; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd02641; R3H_Smubp-2_like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034072; R3H_Smubp-2.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF265; DEAH-BOX RNA HELICASE, PUTATIVE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EAN94644.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 134..198
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 309..472
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 563..736
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1262 AA; 142355 MW; 552256F9DDE15CE6 CRC64;
MPGRRTHKRS NHPADFAAPP LNTISTGYPF HVSQLQQMLY PGAAQNGMFQ YVSQTPPVRY
VFTQRNYSSA FGNVPVDHPQ GNRTTFSSRN QMDRMGHERS RGMMVNQNPF QEQNSVPVTA
VANSKVSICN EEGVWTKKNL YAMVKAFVDD PNAEEMSFPP TLSAAERHMV HEIALNFNLH
HRSAGCKSER VLTLKKIGSI KNQEKDRENA AFNGDRVKTI DGYQGAQRLP DEYIKSRMNE
ISLLLGPFLR KMYSQLKATA AKPLRNRHLV VVQPGLMKAP QGNTQHQRYR ELQEFRRSLP
SYKRRDEIIN ALKQNNVLIV SGDTGCGKTT QIPQILYDSE VFQKDLEIIC TQPRRISALS
VAQRVAEERG ETCGNSCGYI IRFDNMTSPS TKIVYMTTGI LLRRLHTDPQ LNGVSCIIVD
EVHERDVETD FCLLLLRDRL IEQQRNNQLY KNHVKVVVMS ATVQIEKVAS YFVCVCGGRA
PPIISIPGTL FPVEECFLEE ALKWTHLPPS AVPAISMLAN VSEKKSKNGN SEDRNDGSIF
EKIKATVFGE TDNDPEVLVP YDLVFKLISY IHASSHDLSE SILIFLPGWA SISRVNTMIQ
RSPIARELSV LQLHSSLTAA EQQRVFYRPP KRFRKVVLST NIAEASVTID DIVYVIDSCL
TKGTSYDARG NTSVLKATFI SKANGMQRRG RAGRCRAGVC VHLLPRSAYE KLPEFLLPEI
MRSPLEDVCL QVKALKPDEV CAKVLSRAMD PPPADSTEHA VRFLKDMGAF TSEKEQMTNL
GRALSKLPIH PLLGKMLLAA ACLGVLEPVV TIAAYLSGKS PFIKPLPHQK NAMRNAVQSI
DNGLLSDHLS VMKLFDEWKK SNCSADYAMQ NFADQTVLRS MDRIRKQLLR LVKDSSLLRK
VEDPMRMASR HSSNLGLVRL VALWSLYPRI ASVEYRANRS RKRPEIFCWD NKVAQCAMGS
ALAFKNRDDF RDRAFVFYHE RMYLEANLTV FDASAVTPVE VALCLREFAL RPLTDVPPAF
LTDDESKMAP AFPFVLEREE EAKDLAVLFF DGDKKLYVTS LPVGLLLRDV RECMDYYLAL
SIKEVRADLF PEDLIRVLAY VVGYPFSDEV SAIDNNTSDK PVVTYGEEES LEPTTIDCRS
AQLNDISDDE DDAPEIFMED FEDLQMTEEE IQRAIDVFGE LAILNRQGGL RLLGAFEKGV
QLRQVEADLS RGPEGDFFSE EREQKLRNED AKKSDECDDE EDEDDDIIIA KAGELDIDDN
EY
//
