ID Q4DW32_TRYCC Unreviewed; 1055 AA.
AC Q4DW32;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=Tc00.1047053507681.220 {ECO:0000313|EMBL:EAN96745.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN96745.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN96745.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN96745.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN96745.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01000134; EAN96745.1; -; Genomic_DNA.
DR RefSeq; XP_818596.1; XM_813503.1.
DR AlphaFoldDB; Q4DW32; -.
DR SMR; Q4DW32; -.
DR STRING; 353153.Q4DW32; -.
DR PaxDb; 353153-Q4DW32; -.
DR EnsemblProtists; EAN96745; EAN96745; Tc00.1047053507681.220.
DR GeneID; 3550865; -.
DR KEGG; tcr:507681.220; -.
DR eggNOG; KOG0922; Eukaryota.
DR InParanoid; Q4DW32; -.
DR OMA; PERWEMK; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:EAN96745.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 403..566
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 588..768
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 299..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 114..141
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1055 AA; 120565 MW; 30B701A461B0FCAB CRC64;
MQEEVPFLWK LQLIYSRNEL YRQLEHLLGR PESVEQAEGY YDDVEELVGL FLREGGNAGG
EESLLAALNS AINAAGDDEP PIPLEQLRGL VRLMQTNLRG VDWPKCLEAG ALAIAEKERS
EAEAALRLKL LQQEEEEAAQ RDERGRRALE SLATDAAERR AAMKVRAEEK MQLAQLVRSG
LLDESELLQL RTDDEEVEQV ELNEEEPRFL RGLVRHRPIN YRALLPSEQL MRASTPAQRE
AIIARRAMQQ TTADEIETNS MKRAAISQQI RNKDRQILRA KERRLQRLTE HARCGVDDGF
ARRNRGANDG EGEEEEEGGW EAKGNGQYNG NADDNGILGH ELLERPEDRA GGFRSSRDLP
SRLPPWMKHS FGEKPRFGPT FTSQSITEQR QSLPIYAYRE RFLEHVDKHI VTVLVGETGS
GKTTQIPQYL AEHGYSKRGV VCCTQPRRVA AETLAIRVAE EYGCRLGEEV GYTVRFRDVT
SSLTKIKYMT DGMLLREALL DDTFQRYSVI ILDEAHERSV NTDLLFAIVR NATHKRPTLK
VIVTSATLER EKFCNYFNVA DVFFIEGRTF PVEVNFLREP TEDYLDCALR TVMKLHLQEP
PGDVLVFLTG QEEIELGGER LFRWMEKLRE YSERPVPDML VLPLTASLPQ EVQSRVFEPT
PPRCRKVVLA TNVAETSITI TNLYFVVDSG FCKQNVFDPK TGMEQLKIVP ISQAQAQQRA
GRAGRIGPGK CFRMYTELQF QMDMEPATVP DIQRSNLFHV VLQLKAMGIN DLFALDLMDP
PPRETLVSAL QKLRYLEALD DDGLLTPLGG RMAQLPIDPS QSKTLLTAVD MGCCEPVLTI
VSMLAVQKRG VFYRPRDQHE ASDAAKRQFH QPEGDQITLL AVYDAWVANG LSEEWCKRNF
LKHRILMEAR DTREQLSDML RKRHASIPHH NDDALTEVRR AITAGYFFNV AKRITDVAYA
TLAERREVYV HPSSCLRDAP PKYVLYNELQ LTNREYMREL LVIEPQWLVE LAPAFYSRPR
KGKLTKEQRA ERLNPILRAW ENGSSWRISK LRRRK
//
