ID Q4DX27_TRYCC Unreviewed; 508 AA.
AC Q4DX27;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 8 {ECO:0000256|ARBA:ARBA00020983, ECO:0000256|PIRNR:PIRNR015415};
DE Short=COG complex subunit 8 {ECO:0000256|PIRNR:PIRNR015415};
DE AltName: Full=Component of oligomeric Golgi complex 8 {ECO:0000256|ARBA:ARBA00031347, ECO:0000256|PIRNR:PIRNR015415};
GN ORFNames=Tc00.1047053508831.20 {ECO:0000313|EMBL:EAN97066.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN97066.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN97066.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN97066.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000256|PIRNR:PIRNR015415}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395, ECO:0000256|PIRNR:PIRNR015415};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395,
CC ECO:0000256|PIRNR:PIRNR015415}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the COG8 family. {ECO:0000256|ARBA:ARBA00006419,
CC ECO:0000256|PIRNR:PIRNR015415}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN97066.1}.
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DR EMBL; AAHK01000116; EAN97066.1; -; Genomic_DNA.
DR RefSeq; XP_818917.1; XM_813824.1.
DR AlphaFoldDB; Q4DX27; -.
DR SMR; Q4DX27; -.
DR STRING; 353153.Q4DX27; -.
DR PaxDb; 353153-Q4DX27; -.
DR EnsemblProtists; EAN97066; EAN97066; Tc00.1047053508831.20.
DR GeneID; 3551281; -.
DR KEGG; tcr:508831.20; -.
DR eggNOG; KOG2069; Eukaryota.
DR InParanoid; Q4DX27; -.
DR OMA; QRCIHGV; -.
DR OrthoDB; 121534at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR InterPro; IPR007255; COG8.
DR InterPro; IPR016632; COG8_Metazoal_Plant.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR PANTHER; PTHR21311; CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8; 1.
DR PANTHER; PTHR21311:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8; 1.
DR Pfam; PF04124; Dor1; 1.
DR PIRSF; PIRSF015415; COG8; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR015415};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR015415};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR015415};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR015415}.
SQ SEQUENCE 508 AA; 56401 MW; 22BE5B279F56B620 CRC64;
MEVRMSDEEG VRRSIVEATV EHYSLLAETQ EVNAKVASAS GNALSCVRRL NDSLGRLQTL
SQEMIRVGKQ WRREKQIALG TVSQHQKLLA FLEAPAVLDD CIRNEMYHEA LMVLEHINRS
AQTMATVALF RRVEMEARCN LERALSEIVL PRLAEQLTVA SAVKVTTFFR RLGVGEGQVR
QLFLWKRAEY VDGLLREAEE SGVPYSRIFR YVTAFKVHVT ETILQYAACF SPTIENGSCS
ELAAWCHERA YVFLEGFRAS LEKITNGSEL ASVIEECKSC CATTTLLQMD VSGLINESLI
SRARALFAEQ IALAMQSYSA SMLAFSWRPS NGLQFASLQK RVETAPSSSN GIISPPLSLV
QWLPLAYALN GVLTAFNTIR KCVVPGVELF CAAKLEGLLQ TIAKDLSRDK DLLMAMEGGE
KQFYLLFVEA FVNDFYPHVL ACMRELLGED AQRLLINGVR ESIESLRSLL FMESSTTQSG
VPQQQMTDAA GTPADIQGDR ITPNVVGA
//
