ID Q4DY53_TRYCC Unreviewed; 917 AA.
AC Q4DY53;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAN97431.1};
GN ORFNames=Tc00.1047053511727.50 {ECO:0000313|EMBL:EAN97431.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN97431.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN97431.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN97431.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR017179}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN97431.1}.
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DR EMBL; AAHK01000099; EAN97431.1; -; Genomic_DNA.
DR RefSeq; XP_819282.1; XM_814189.1.
DR AlphaFoldDB; Q4DY53; -.
DR SMR; Q4DY53; -.
DR STRING; 353153.Q4DY53; -.
DR PaxDb; 353153-Q4DY53; -.
DR EnsemblProtists; EAN97431; EAN97431; Tc00.1047053511727.50.
DR GeneID; 3551713; -.
DR KEGG; tcr:511727.50; -.
DR eggNOG; KOG2039; Eukaryota.
DR InParanoid; Q4DY53; -.
DR OMA; EKTCCTV; -.
DR OrthoDB; 375531at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016442; C:RISC complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:InterPro.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 5.
DR InterPro; IPR016685; Silence_cplx_Nase-comp_TudorSN.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR12302; EBNA2 BINDING PROTEIN P100; 1.
DR PANTHER; PTHR12302:SF2; STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00565; SNase; 2.
DR Pfam; PF00567; TUDOR; 1.
DR PIRSF; PIRSF017179; RISC-Tudor-SN; 1.
DR SMART; SM00318; SNc; 3.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF50199; Staphylococcal nuclease; 5.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50830; TNASE_3; 3.
DR PROSITE; PS50304; TUDOR; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR017179};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..143
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 338..486
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 522..654
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 733..793
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
SQ SEQUENCE 917 AA; 101311 MW; 4D1E4FC58801F173 CRC64;
MSYIVFAVDN ADRLTLLGPP TPEGPNLKQI ALSFIQAPKL ARRSSTGEFG PEEPFAFEAV
ELMRTTFIGK PVKFTEDYVI DVLQRHAGRL ELSGGEDASV LLLQNGFATV SEHIPARMEK
TLFAKYSALM NEAKMAKKGI FAPDAASHTR VLRDLTAEET SKLGEKLKGK VVLVRVEQVL
SPTICMVSAE KFPRTQISVR MPGVTIKDSD CLAVSTAARF HTERYLLHRK VKIAFEGWIL
LVHSWLSDFL QGCISTELLL HGFVKINVST LAFTNHADAL RAAEKEAREK RQGLWKNWEE
SGESGTLQVK YGTAAAEAPG LAVNNANSND GPEYKGPLSF SAVVVQIVNG DTITVRSDEK
GELIRVSLAG VRSSKNVTRE QDGRSPETRV SYTDYEWEAR EFLRTHYIGK RVIVQVEYAR
QIFETKEVRP VVLVKIPETG ANIGLSLLET GYATFLLGKN DVCSEASLLQ IAAEKAREKG
LGTYGKGKPP VQKIVELHHL GNARGKYYLS FLQRGMQGNR PPLLKGVVDA VLGGGSLRVY
IPKENFQIPV KVAGIITPMG AANSSETADP FAEESKDFAV TRLQQFNVEI QVHTVDRAGN
FISTVFLPDG TNFSIATVEA GLGTVANADR LPYYQQLIDA EKKAQKEGKY IWSNQSSIPQ
RAAKLMAERN ANGVNCYSRS FGPKSEFIPY VLSEVGEDGY SVYLQEQGDE NEERLETLQD
LANKVSSLNG EYQPKRGELV VAQYRKDKSW HRAKVLHAKK GEQIVTVLFV DFGTVSETSV
KSVRAIPRGP EFALLRDLEP LARLVRLAFL KSKVPSPEAN AGYACDVAYE YTDGAVIAKE
VYQDGQGNVY YTVTVNENVP SLSETLLQRG VALLDRIAES VDPSEYQRHE AAQAIARRSH
KGMWQYGDID DESDGEI
//
