ID Q4DYD8_TRYCC Unreviewed; 799 AA.
AC Q4DYD8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=EF-hand domain-containing family member C2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Tc00.1047053506321.300 {ECO:0000313|EMBL:EAN97553.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN97553.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN97553.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN97553.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN97553.1}.
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DR EMBL; AAHK01000094; EAN97553.1; -; Genomic_DNA.
DR RefSeq; XP_819404.1; XM_814311.1.
DR AlphaFoldDB; Q4DYD8; -.
DR SMR; Q4DYD8; -.
DR STRING; 353153.Q4DYD8; -.
DR PaxDb; 353153-Q4DYD8; -.
DR EnsemblProtists; EAN97553; EAN97553; Tc00.1047053506321.300.
DR GeneID; 3551834; -.
DR KEGG; tcr:506321.300; -.
DR eggNOG; KOG0043; Eukaryota.
DR InParanoid; Q4DYD8; -.
DR OMA; TFAHRVN; -.
DR OrthoDB; 167477at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 2.30.29.170; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR PANTHER; PTHR12086; EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12086:SF17; EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2; 1.
DR Pfam; PF06565; DM10_dom; 3.
DR SMART; SM00676; DM10; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51336; DM10; 3.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 104..216
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 268..392
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 450..553
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 575..610
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 799 AA; 91046 MW; AD9F46EE48EB74CF CRC64;
MTSPTPVALG HDVPTEYIRT LDPKLLPPRV GHNWLDPAFR KVQDKPQQLE LEFRGKRAFT
AKGIYDHTPP KGLGLTAQQL LHALSTRRKG GIEADRRAQY TTLSDKVLRF YAFFTEKAPD
GCIEDYWHRR VVIHFFPEDN TVLIQEPCIP NSGLSGGTFL KRQSVRADPR QREEFPDEEF
LSLNHFNVGR SVRINAVEFF LYDCDVFTRE FLTALGVDVG SPVSCPDSSF MSDWKKYQER
MLSGKFGILS QEYHGDEAVR AARFVHDSGK VLRFYSLLDE RNKVPVGIVR KLEVLYFVED
DSIAVVERPT SNEAVPSLFL SRGWLPKVGS IAKANELTFA HRVNGMRQPY IGPEGHYTAI
DLGVGITINV LGRSVFLYDC DDYTRSYYLE TYGVKLSDAV DCSIDYGISP ESRVTAFRLT
STPASVPLTA VASTGGEHAF FSDKRTGPKT KDVLRFLLRL APPCSVVERQ RRFTLTYYTD
TDDAMVFESP VRNSGFVGGC FCSRRRLPKQ GGDAEAYYTI SDFSVGGFIV VNGHKFEVMN
MDEHTRNYLA GKNDPVMNDE RLHLLISAFR LFLGTRFHSF KDAFLGFDRD KDGVISVTEF
VGHLQDLQIT ERRLDGEALF NHIASCSETG YLTMEDFVRW MSETATDKGQ KNYESIDVDE
RAVMRKALLQ LCERLEARCL NSLQMFRLAS TMPRAYTERR ADIYSLANPH RDALVTPVQL
RRCIEEVLGG NPSPREMDAL LSFFFPQLPL EEYRSRRDGD LEHALDLKAF QKKYHEMNKL
LMLSEPSKQQ QQTQQRQQE
//
