ID Q4DZX1_TRYCC Unreviewed; 653 AA.
AC Q4DZX1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Glutaminyl cyclase, putative {ECO:0000313|EMBL:EAN98067.1};
GN ORFNames=Tc00.1047053506789.180 {ECO:0000313|EMBL:EAN98067.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98067.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98067.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98067.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98067.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01000072; EAN98067.1; -; Genomic_DNA.
DR RefSeq; XP_819918.1; XM_814825.1.
DR AlphaFoldDB; Q4DZX1; -.
DR STRING; 353153.Q4DZX1; -.
DR PaxDb; 353153-Q4DZX1; -.
DR EnsemblProtists; EAN98067; EAN98067; Tc00.1047053506789.180.
DR GeneID; 3552468; -.
DR KEGG; tcr:506789.180; -.
DR eggNOG; KOG3946; Eukaryota.
DR InParanoid; Q4DZX1; -.
DR OrthoDB; 3091175at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.630.10; Zn peptidases; 2.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR040234; QC/QCL.
DR PANTHER; PTHR12283; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR PANTHER; PTHR12283:SF6; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 258..298
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 653 AA; 75335 MW; 00849599C0605333 CRC64;
MQNRTRRPLR EMAIKTNDYN RNIHVKGRPI VDKKICCLAI ITLTAFVLAL GIISPWYWKD
MLFNKENEET MKSLWDREMH PSLREHPWKT SYPPLKLQHT HSEEDEEEEA VFSALSFFLP
ASQRRVRLMQ RIQKVLQFGT RVAGSFSPGH RKMLEFIAAE GQWQPQLTTL FNPTVIQPSP
RSHWRLEWDN FTSETPLGAR WFFNLAFHFE GGHAFRQQSS KETKKKEATT VKRSRRSFAA
AAGGRNGEGK SSMAGEKLRH VVLAAHWDSK YFAEFDFLGA CDSAVSVVYL LETMRMITVL
SETSEILQSL TENAEKKDFC TQLRHALSPA YRKILLYYYA DDDDVIHCLS GNTTTRMAGN
GTEDENVSNC EENFGDGDGG GGVAWQKLLR HVSHLPAITV IFFDGEEAFV RWYDDDHTYG
SRHLAQQWKK KKMQPVVTDA YNRADTTLSY FDSIDLFVLY DLMGPAETQF HNYFPDQSGM
AFALLVDVEE AHRLRAERLS CIVQQFMREK ENCSSYLPEI WCQHGTPHEM YTLSDAPCLM
APLRPHIDNA EKSFPSNDTS QAHSIGLRVR NLFFPMEEKL AQGSQLDNTF AMEDDHIHWM
DTQRVLHLIP WPFPPSWHTV RDDGREIDEG TVMDLLRVLE EFVLYLGEGW IHS
//
