ID Q4E0A5_TRYCC Unreviewed; 722 AA.
AC Q4E0A5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN98216.1};
GN ORFNames=Tc00.1047053509287.230 {ECO:0000313|EMBL:EAN98216.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98216.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98216.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98216.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98216.1}.
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DR EMBL; AAHK01000066; EAN98216.1; -; Genomic_DNA.
DR RefSeq; XP_820067.1; XM_814974.1.
DR AlphaFoldDB; Q4E0A5; -.
DR SMR; Q4E0A5; -.
DR PaxDb; 353153-Q4E0A5; -.
DR EnsemblProtists; EAN98216; EAN98216; Tc00.1047053509287.230.
DR GeneID; 3552641; -.
DR KEGG; tcr:509287.230; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4E0A5; -.
DR OMA; HKAPNEG; -.
DR OrthoDB; 128797at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 108..444
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 78503 MW; 3C05278AE3762FC2 CRC64;
MLSRVAAVKA PRTHSRRRVT GSSGRRREGG ESEPQRPNMS RRVFTFALLL PLVVMMCCGS
SGGAAAVGSV SEDEHLSKWV DIFVPNKTQV LAGEDDSKSG VGVSFVSPSL VSAGGVMAVL
AEGIISYNPS GATETFVYHS DIVAGYVNAA ESWPSLVAEI NDGTWRAHTV LSTVNEERHV
GIARFPTTIA KGNKLFLLVG SYIMMQDTKD DFWKLGGTDI QLVQGEATKS TEGKQSKSIK
WGEPKSLLGQ IAPQAQGDSK VLWAGGGGSG VLMEDGTFVF PLQKRKENGE FLSMIIYSTD
DGSSWTLSRG MLPAGCRGSC ITEWERGQIL MITDCDDGQR VFESRNMGTT WTEAVRTLLG
VWVKSESEFF WDKSLRAGAL ITATIEGRKV MLYTQKRYPT QEQKDKALYL WVTDNNRTFY
VGPFSVDSAE NKTFANALLY SDAELYLSQQ RGIKTGTAVS LSRLAEEMNT VRSVLSGWAQ
LDASFSESFT PTAGLVGFLS NAASGDTWID EYRCVNATVT KAAKVHNGFK FTGPGSRAIW
PVNSREDNNQ YGFVDHNFAI VATVTIHKAP KKSTPLLGAS LGEGHPTKMI GLSYGAGSKW
ETVFDGKTTA QDSTWEPGKE YRVALMLQGG NNGSVYVDGK LVGSSETIPT LETTVLEISH
FYIGGDEGDS DSDLTVKNVF LYNRPLSADE LKMVTKREDS VRGDVSRVLL LLLGLWGIAA
LY
//
