ID Q4E0J2_TRYCC Unreviewed; 869 AA.
AC Q4E0J2;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN98292.1};
GN ORFNames=Tc00.1047053509897.140 {ECO:0000313|EMBL:EAN98292.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98292.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98292.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98292.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98292.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01000061; EAN98292.1; -; Genomic_DNA.
DR RefSeq; XP_820143.1; XM_815050.1.
DR AlphaFoldDB; Q4E0J2; -.
DR SMR; Q4E0J2; -.
DR PaxDb; 353153-Q4E0J2; -.
DR EnsemblProtists; EAN98292; EAN98292; Tc00.1047053509897.140.
DR GeneID; 3552739; -.
DR KEGG; tcr:509897.140; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4E0J2; -.
DR OrthoDB; 5577481at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..436
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 91655 MW; 7F3DDEAE0789F79E CRC64;
MLSRVAAVKA PRTHNRRRVT ESSGRRREGG ESEPQRPNMS RHLFYSAVLL LVVMVCCGSG
AAGVAEEPAV STFKWRGINE GGGETVDSLG APSLLKVGSD VFAVAEAQCK KNGGVDFTGV
ASQPLTTEAA KTPVEVLEKP KDWTKVLEEG ASDDAKTKVD VSRPTTVLKG SDIYMLVGQC
GSKESPNSGA GGCELLLVKG SVSGGEGANN KKIDWEDPEN SPQRIFDKQP DSWTRLVGSG
GSGVEMKDET LVFPVEGTKK AAEGTVVDVK TVSLIIHSKD TTNWTLSKGM SDGGCSDPSV
VEWEKGKLMM MTACAGGRRR VYESGDKGDS WTEALGTLSR VWGNNKKDGQ ATAVRSGFIT
ATIDGVDDKK VMLVTLPVYA EKDKEKGKLH LWLTDNTHIV DIGPVSGEDD DAAASSLLYN
SGKTDDNDEE LIALYEKKKD VKPPPGMVSV LLTEQLKRVK DVLTTWKEVD GRVSQLCTSL
SSEKERASTD DFCGAVKITA GLVGFLSGNL SGNTWRDEYL GVNATVNNKA GEAASAVTST
KNGVKFTGRG AGAEWPVGKQ GENQLYHFAN YNFTLVATVS IHKMPQEGDT PVPLMGVKMK
NAGNSVLLGL SYDSGKKWHV LCGDKTTTKL SSTWETGTPQ HVVILLKNGT QGSVYVDGQR
VGGNGECALG NDESKEISHF YIGGDGENAD KEGVSVTVTN VLLYNRPLDE AEMAAFNPNK
APTPSLVDGS VEGGAIQFSG GGRPEEQRQS LGSSGVNGVS APTVSSAKTS SGGEGSATQL
VSEKSSDGHK NVDGGFFSDG EPTVETREGG TNGREEEIHA QNGDVKAAAL SNSLGNVSQG
NNSDAGTKRG SGLLPSLLLL LGLWGFAAL
//
