ID Q4E0J5_TRYCC Unreviewed; 875 AA.
AC Q4E0J5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 08-NOV-2023, entry version 73.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN98289.1};
GN ORFNames=Tc00.1047053509897.20 {ECO:0000313|EMBL:EAN98289.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98289.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98289.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98289.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98289.1}.
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DR EMBL; AAHK01000061; EAN98289.1; -; Genomic_DNA.
DR RefSeq; XP_820140.1; XM_815047.1.
DR AlphaFoldDB; Q4E0J5; -.
DR SMR; Q4E0J5; -.
DR PaxDb; 353153-Q4E0J5; -.
DR EnsemblProtists; EAN98289; EAN98289; Tc00.1047053509897.20.
DR GeneID; 3552734; -.
DR KEGG; tcr:509897.20; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4E0J5; -.
DR OrthoDB; 5578000at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..438
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 92347 MW; 4F1A6B21C3D8422A CRC64;
MLSRVAAVMA PRTHNRRRVT GSSGRRREGG ESEPQRPNMS RHLFYSAVLL LVVMVCCGSG
AAGVAGEPAV STFEWRGINE SETVDSLGAP SLLKVGNDVF AVAEAQCKKK AGDVSFTGVA
SQLLTTKAAE TPVEVLEKPK DGTQVLEESA SEGQKKKVDV SRPTTVLKGN DIYMLVGAYN
NVAAPGQVDA SDAAQLGLLL VKGSVNSGDA SNKKIDWKDT ESSPQRLFGA QPDSWTKLIG
SGGSGVKMHD ETLVFPVEST KKAAEDAEED VKTVSLIIQS KDTTNWTLSK GMSDGGCSDP
SVVEWEEGKL MMMTACGDGP RRVYEIGDMG ESWTEALGTL SRVWGNNKQG VSGVRSGFIT
ATVGNGDNKK VMLVTLPVYA EKDKEKGKLH LWLTDNTHIV DIGPVSGEDD DAAASSLLYN
SGETDDNKKK DELIALYEKK KGNDVKPSPG MVSVLLTEKL KRVKDVLATW KEVDGRVSHL
CTSLIAEKDR ASTDDVCSAD KITAGLVGFL SGNFSGNTWR DEYLGVNATV NNKAGEAASA
VTSTKNGVKF TGRGAGAEWP VGKQGENQLY HFANYNFTLV ATVSIDNVPK EGDTPIPLVG
VRAGSNGEKT KLMELSYNSE KKWHVLCSDK TTKEPSSGWE TETQYQVAIV LQNGTQGSVY
VDGQRVGNEE CALGNGESNE ISHFYIGGDG ENAANKEGVS VTVTNVLLYN RPWDEAEITA
LNPNKDPTPP VTPNAQKTGT SSALDGSHLT ERGQSMGSSG AGSGGASPSA VPTVSTPSAG
KDSLQQVASG KSSDGTRTVD GGSFSDGEPT VETREGGTNG QEEEIHAQNG DVKAAALSSS
LGNVSQGNNS DAGTMRESGL LPLLLLLGLW GFAAL
//
