ID Q4E0M7_TRYCC Unreviewed; 1133 AA.
AC Q4E0M7;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN98335.1};
GN ORFNames=Tc00.1047053510307.284 {ECO:0000313|EMBL:EAN98335.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98335.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98335.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98335.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98335.1}.
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DR EMBL; AAHK01000059; EAN98335.1; -; Genomic_DNA.
DR RefSeq; XP_820186.1; XM_815093.1.
DR AlphaFoldDB; Q4E0M7; -.
DR SMR; Q4E0M7; -.
DR STRING; 353153.Q4E0M7; -.
DR PaxDb; 353153-Q4E0M7; -.
DR EnsemblProtists; EAN98335; EAN98335; Tc00.1047053510307.284.
DR GeneID; 3552807; -.
DR KEGG; tcr:510307.284; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4E0M7; -.
DR OrthoDB; 140204at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR24216:SF65; PAXILLIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR24216; PAXILLIN-RELATED; 1.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 103..424
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..771
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..883
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..1020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 120291 MW; 2FEDF5768CD3F508 CRC64;
MLSRVAAVKA PRIHNRRRGT GSSGRRREGR ESEPQRPNVS RRVFTSAVLL LLFFLACAAA
GPVQAQNYGT RVGDSYGRHS LEQLQRGHQA ANPPIPGHIF RNPHLVNVNG MLLAIAGAQF
NRTVGSGSAS MQLMAHISVD GGRTWRSYAG PEDLDAFAAS PHRMSFPSSF GPLGSIFAFV
EGCDLRKGVR PHYANRWGGS GVESVIHFLE TGPRRSGGLS MSSVSMSIRL PYPHKSGDMI
GFLNDASTPI TKMTDGTLVF PVQFLTMGGD TASTIMYMNP GQQHWTFANS ATHAGCIEPS
ILEWEAGKII MITSCKYGRR RVYESTDKGN TWTEAVGTLS RVWSNPLAGS GLHIQGGFIT
ATIDGKKVIL LTQLEYFGDK ERSEIHLWLT DTNRIYQVGL LPTGNSATSS SLLYANDKLY
CLYEASVGSD SVPYPLDLTL ELQRIRHALS TWAVKDNALR QCGLMASGAA LSRGNCSVPI
PMAGLVGHLA DTLRGDKWED EYLGVNAVVR GAAKKAPSGW TFEGHDAGAE WPVGKQWPKM
PFHFANYGFT LAATVSIHEV PKGITPLMGL KKMGKTTLLG LSYDNNMEWS VEHELFPKHF
TAWELDKTYH VVLKMHDGVG SVYVDGTLLW NMSLRNSFNE GLDAVSHFYF GAYDEQLSSG
KIHATVANVF LYNRPLNETE IGALNANKVT IPPPERKSAK ASTATSPSVE SANDRVNTNT
QPTVPAPTPA APQPTEQATL NTSSVPSGGA PSTPAEPKSA GPKPAEPKSA GPKPAEPKSA
EPKPAEPKSA EPKPAEPKSA EPKPAEPKSA EPKPAESKSA EPKPAEPKSA EPKPAESKSA
EPKPAEPKSA EPKPAEPKSA EPKPAEPKSA EPKPAEPKSA EPKPAESKSA GPKPAEPKSA
EPKPAEPKSA EPKPAEPKSA EPKPAEPKSA EPKPAEPNSA EPKPAEPKSA EPKPAEPKSA
EPKPAEPKSA EPKPAEPKSA EPKPAEPKSA EPKPAEPKSA EPKPAEPKSA EPKPAEPKSA
EPKPAEPNAA TSSAREGTAD QPASATFSDG HEAVTSVIFS SAAITDVGAS SSDDAQTVGT
EGGAVMQADQ PTQFSVGTPD AANAATHNAE RKGQEGLHPQ VKEAEAATLS SSL
//
