ID Q4E0M8_TRYCC Unreviewed; 1050 AA.
AC Q4E0M8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN98333.1};
GN ORFNames=Tc00.1047053510307.240 {ECO:0000313|EMBL:EAN98333.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98333.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98333.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98333.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98333.1}.
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DR EMBL; AAHK01000059; EAN98333.1; -; Genomic_DNA.
DR RefSeq; XP_820184.1; XM_815091.1.
DR AlphaFoldDB; Q4E0M8; -.
DR SMR; Q4E0M8; -.
DR STRING; 353153.Q4E0M8; -.
DR PaxDb; 353153-Q4E0M8; -.
DR EnsemblProtists; EAN98333; EAN98333; Tc00.1047053510307.240.
DR GeneID; 3552802; -.
DR KEGG; tcr:510307.240; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4E0M8; -.
DR OMA; EDNGNGR; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR022144; DUF3676.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF12429; DUF3676; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 102..434
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT DOMAIN 732..961
FT /note="DUF3676"
FT /evidence="ECO:0000259|Pfam:PF12429"
FT REGION 13..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1050 AA; 113522 MW; 8C7698DBBD19948B CRC64;
MLSLVAAVMA PRTHNRRRVT GSTGRRREGR ESERQRPNMS RRVFTSAVLL LLAVMMCFGT
DGAAHAEQAG AGFDPFTGTT SISFANWREF KEDGGEITSL RVPGLVKVGD DVFAVAEAQC
GERNGADSCA GIVSKHLNIS DDLMDISTSD ISLFRMQLVG TAANNFGTTE LLRPTTLVIG
DSVYMLLGNY SRKKPQVVGK NERGLLLVKG TVTVDGGKNK KLVWNETHVV NPQRKGESLL
LTEFLGGGGS GAVMGDGTLV FPMQAKGKDG TSFLLSMSFD PSDKKWELSS ETPGKGCRDP
TLVRWEEYEY GERLFMMAHC AGGYYDVYKS TPHGVNWYTS GEPITRVWGS SHNRKGYGVQ
SGSTTAIIEE KEVMLITAPV YAKEDNGNGR LHLWVTDKAR VYDVGPISRE DDDAAASSLL
MKGKDNKELI SLYENKKKDG TYSLVAVHLT EKLERVKEVV KTWKDLDSAL QSCSSGSSGT
LDLPKKGMCN GPVPTDELVG FLSGNSTGTE WRDEYLGVNA IVHGPAEKRI GVPNGLTFKE
AGSWAEWPVG KLGQTVPYYF ANNKFTLVAT VSIHEVPKED SRPIPLIGVR MNDTSSTVLF
GLSYTHDKKW LAITEDADDP EDVDYIVKWD PNKTYQVVLR MTLDEWTVFV DQREIDRKSY
NKHLFDLHRI SHFYIGGDSK DESATGGHVT VTNVMLYNER LLSDKLYELN ASKVNIPSLG
VEKQPTGPVI STGLPVASES KSEESTASYA KLNEDDPEKQ RRKNGVDDPV PAAPPSTVVA
GSSVSEPAIA AESAGNDRPD DNAQFHQGKT AQQATLSEEN KSVQRGSDLQ PQDPQPAELT
EVADVEGSSE GYGTQQPVEE EGTNGRGGGS TSSVGASSDM DTATETVDSE HQVQQSTEPS
AENDDVRSTG TGTTGAEESL SLEARDGSSE RTMSSDSSLT PSKSDAEPTS AEDTDNISRT
EEAEFLVENG EEAPQTVETA SGNTNTTPGE TEIPSESNAT TPSDTDILLE NGHLGELAAM
YLIGDSTVHG CVSRVLLLLL LGLWGTAALC
//
