ID Q4E159_TRYCC Unreviewed; 869 AA.
AC Q4E159;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE SubName: Full=Calcium/potassium channel (CAKC), putative {ECO:0000313|EMBL:EAN98530.1};
GN ORFNames=Tc00.1047053511585.220 {ECO:0000313|EMBL:EAN98530.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98530.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98530.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98530.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98530.1}.
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DR EMBL; AAHK01000053; EAN98530.1; -; Genomic_DNA.
DR RefSeq; XP_820381.1; XM_815288.1.
DR AlphaFoldDB; Q4E159; -.
DR SMR; Q4E159; -.
DR PaxDb; 353153-Q4E159; -.
DR EnsemblProtists; EAN98530; EAN98530; Tc00.1047053511585.220.
DR GeneID; 3553017; -.
DR KEGG; tcr:511585.220; -.
DR eggNOG; KOG3193; Eukaryota.
DR InParanoid; Q4E159; -.
DR OMA; QRTYFME; -.
DR OrthoDB; 2907493at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF37; CHANNEL (CAKC), PUTATIVE-RELATED; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 32..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 194..251
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 404..491
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
SQ SEQUENCE 869 AA; 98578 MW; 790AD357CC994742 CRC64;
MFEPRSQMAY RQDTFRNIRS LRKLFEVMDQ KYSSISITFL IIHLIMELAS VVFYVWTAVV
SEATSVSEFH WNGTMFNIEF GLNIVFFLEW VALFFGEDDK IGYCLSWLSI VNAMTSIPMI
VIGIGGLTET SWRSYWVPMY LRVWWLRDCV VVLLDYPQVE RWMKDVTREV CRFVATLFAG
LCTCAGTLQI VESTTGSYMN PFNAFYCMVV TFSTIGYGDI VPGSTPSRLL MAVFIVFAVS
HFMPLFQRLV SISRQRLHYN VYNSRGGRKA HVILAGIFTK LGVKIILQDF YGGWRRYVDL
RIVLLSPVEH PLEVKLLVNL PWFKDRVLLM IGDPQKESDL KRADARHADA IFLFGDTFPA
TFHTDYTLIQ QSLSINNHDS ELAQYLYLRS ERNTKHVASY AAGVVEGERL LHHLLGLGVV
VPGAIPLIVN LLRTYDPFTL DMKRTLHWVE QYELSLQHNI FCIDVPDAYR GRDFHRLARL
FFDHDVTLIG VITTGGMVQL NPSRVAALVG KIIFIAKGPE EVKNAMTEVE ETRFSTIDPE
ADDQPCYPTL VLSSERNGST SWAGEFSGHV GSIQQINDAY DFENHFVVID LSIANDRAAE
TEGAHEGTLT SAAVNIFHIM QSIRQTYPQN DIVLLTKDTS FSVYFDRYWH GVKGAIPIKY
VDGCGLNTND LRRCNLKQSA GIVIFVFGDT SGKSTSGVSM LVNLSIASIL PSSHNIPVVV
ELDSLQHLSL FPPYAEHSRL RQKAEVDFVF EPNYIIGNAI SRHMLFPLVH ATYFMPEFID
IIDMIVSGVD EETPSLGRLS LSLSHEVIET YKDVVDYCLS LRYLPIALHI CISDTRNLSL
NGKRFVMTNP PKDLPVDREK DAVFYLLPT
//