ID Q4E3C3_TRYCC Unreviewed; 929 AA.
AC Q4E3C3;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN99251.1};
GN ORFNames=Tc00.1047053508355.80 {ECO:0000313|EMBL:EAN99251.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN99251.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN99251.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN99251.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN99251.1}.
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DR EMBL; AAHK01000025; EAN99251.1; -; Genomic_DNA.
DR RefSeq; XP_821102.1; XM_816009.1.
DR AlphaFoldDB; Q4E3C3; -.
DR SMR; Q4E3C3; -.
DR STRING; 353153.Q4E3C3; -.
DR PaxDb; 353153-Q4E3C3; -.
DR EnsemblProtists; EAN99251; EAN99251; Tc00.1047053508355.80.
DR GeneID; 3553952; -.
DR KEGG; tcr:508355.80; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4E3C3; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..929
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004238030"
FT DOMAIN 60..387
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 568..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..591
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..729
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 929 AA; 101897 MW; 739CDB44FDEEFD2C CRC64;
MSRHLFYSAV LPLLVVLCGS GAAHTVQTKT AVDPFTGIGW TSSQWEAPTK VNETLFSLRV
PSLVEVNNNV FFVAEALCKE KGESRSRTGI ASRHLDLTDD KPKEILTEDT SLVVQFPEGV
ATGTVEAKDT MRPTTVVSGD SVYMLLRNQG VTPLVGKSAN ARDWGLLLVK GSVSGGNGIT
WNETHAVTFE NNEYAAKFLT QLVSGGGSGI KTKDGTLMFP MQATKNENTS LLSMRFDKSE
NKWKLSHQTD VDGCRDPTIV EWGDDRFLMM ASCERGYRDV YGSTESGRSW FPYGETLTRV
WGNSHDRKGH GVQNAFIKVT IEDKDVMLVT LPVYPKEDNK QKGRLHLWVT DNSRVYDVGP
ISREDDDAAA SSLLMKSGNE KLISLYENKK GDDGSYSLVA LSLREQLERI KSVVKTWSAL
DGALKTCHSG SSATVDPRKK GMCAGPVPTK GLVGFLSGNF SDNKWRDEYL CVNATVNNGE
PRVRNGLTFK GPGAGAVWPV GKMGQTVPYY FANNKFTLVA TVSIHEAPKE ASSPIPLMGV
IMKDNSSTAL FGLSYTHEKK WRFTLPNGTY GGVEDDEDDE DYEGAEDDED DEVAEDYEDY
EYYEHDQYYE GKYNWQPNKT YQVMLQMNTK EWYVYVDRMR VYSGHYNWDL FKDHRVSHIY
FGAENKEGSE SSHVTVSNVL LYNRIIYGRG RKMLNASKVS IPNPGEEFLT EKEEETPSSP
EEGKAEQEVG EALPRPQSSV EAPEGSDAAA VSSGIRGSHG KREEETETDG SGELASPPAL
SSVGTSAHSG DDGMGVREGT TLQEEVPPPL GTEDIPKADV ERPIYEEEAT SPEWATERQT
QETTAPLVEN GDGEDVGTAS GNASTLPGET EIPSESNATS LSDHGILPEH GHYSELAGMA
LFAESTVHGC VSRVLLLLLL GLWGTAALC
//
