ID Q4E3W1_TRYCC Unreviewed; 776 AA.
AC Q4E3W1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN99443.1};
GN ORFNames=Tc00.1047053510377.50 {ECO:0000313|EMBL:EAN99443.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN99443.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN99443.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN99443.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN99443.1}.
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DR EMBL; AAHK01000019; EAN99443.1; -; Genomic_DNA.
DR RefSeq; XP_821294.1; XM_816201.1.
DR AlphaFoldDB; Q4E3W1; -.
DR SMR; Q4E3W1; -.
DR PaxDb; 353153-Q4E3W1; -.
DR EnsemblProtists; EAN99443; EAN99443; Tc00.1047053510377.50.
DR GeneID; 3554171; -.
DR KEGG; tcr:510377.50; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4E3W1; -.
DR OrthoDB; 138252at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 753..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..444
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 82641 MW; 46BFE6DB012804C1 CRC64;
MLSRVAAVKA PRTHNRRGVT GSSGRRREGR ESEPQRPNMS RHVFTSAVLL LVVMMCCGSG
GAAQAAEPAS GQESLPSPSF AWRDKKEGET VDSLHAPSLV EMDGGVFAVA EAQLKEGGSN
FTGIASELLE WTDKESRELD TNKLKTQVLE ECPAENKDCA SQTGDQEDSQ SRTKVRVSRP
TTVVKGSDIH MFAGTYSFEV TKGVDQTAAA AKWGLLVAVG NVSNDGSSDK KKIYWNDASV
IPWTYFEKRH ESLTRLIGGG GSGAKMKDGA LVLPVEGTKD GKAVSLIIYT ATGGGNLSKG
MSADGCSDPS VVERKDGKLM MMTACDDGRR RVYESVDKGD SWTEALGTLS RVWGNKHRGN
VKGVGSGFTT ATIENRDVML VTLPVYSKEE EKEKGVLHLW LTDNTHIVDI GPVSGDDDAA
ASSLLYKSAG SGNNNNERLI APYEKKKGGG ESSLGMVSVR LTAQLERVRE VLTTWKEVDE
RVSQLCPSEG AKEDTSTDNA CSAVKITDGL VGFLSGNFSD TTWRDEYLGV DATVKKGTNG
VATGYADGVK FQGAWAEWPV GRQGQNQLYH FANHNFTLVA TVSIHGEPKG DTPNPSMGAT
MNDNKNTVLL GLSYDKEGKW RVLCGGKTTK ELRSNWEPET THQVAIVLRN GSQGSAYVDG
QRVGDASCEL KSTDSKGISH FYIGGDGGST GSKEDVPVTA TNVLLYNRPL DDNEIRVLNA
NKISIPKLTG LKTLAAGATG VGTARDGGAH GDGSTVCGGG LLLLLLLLGL WGIAAS
//
