ID Q4E4A6_TRYCC Unreviewed; 1482 AA.
AC Q4E4A6;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE RecName: Full=SEC7 domain-containing protein {ECO:0000259|PROSITE:PS50190};
GN ORFNames=Tc00.1047053510187.448 {ECO:0000313|EMBL:EAN99607.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN99607.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN99607.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN99607.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN99607.1}.
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DR EMBL; AAHK01000013; EAN99607.1; -; Genomic_DNA.
DR RefSeq; XP_821458.1; XM_816365.1.
DR AlphaFoldDB; Q4E4A6; -.
DR SMR; Q4E4A6; -.
DR STRING; 353153.Q4E4A6; -.
DR PaxDb; 353153-Q4E4A6; -.
DR EnsemblProtists; EAN99607; EAN99607; Tc00.1047053510187.448.
DR GeneID; 3554404; -.
DR KEGG; tcr:510187.448; -.
DR eggNOG; KOG0929; Eukaryota.
DR InParanoid; Q4E4A6; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF375; LD29171P; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 365..553
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 79..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1482 AA; 165367 MW; 8AA49B0DEC8FEA58 CRC64;
MSGSGVSNSL LPHVLSRILA GHRGANSVEQ KKPSMDTTLS CSVDSTMGSN EKQFNLDKCN
TLINSMNITI AASSTDIVAN RQHSAGEEED EEDQQQKQQL TLSDHQDCYA LLVRICDLSI
KVVESRTPAD SMEWRRKRLS TRLLAHLINA VNDEFARSDF FRSALHEKVT LSLLHNCALE
DPVLHGVALK TLYQLVMRYR NLLKSKVVIF ILGLLLPIVN SKNTSYEQKA TILTFFEHTL
RDPQLLMDWF TNFDCVQGMP NLCEQLVSGL SKMSKMSHMS SWVNAKQDAL LRLQCIKALG
TFVRSLEGIA KEFPMGGGIT PRSQERELES RENQEMKSVA AENEKGETGA HSKNNVNSGS
LSECGVEQLL RGKKAFDAVV DKFNLGDHAA AIAMALNVHL LSSAAPEAVA RFLLQKELDP
VGVGEYLGKD NEERKAILRA FIGLNDFSGL PIDDAMRLFL GKFKLPGEAQ VVDRAMELFA
REYCAQNPSS FSGPGPAFIL AFSIMLLNTD AHSSHVTDKM TLEQFVRNNS GIDDGKDLPR
SLLEGVYQRI TAREIVLEAR GAVPSNGLRK CSYGTKDMRP LSSPSSLSSL GARRRNHRSS
RHMEQAYLLE TSVEQITRDV SSEPYTSINS SELVGALMES TWTALLAAFS IPMEEMENIE
LIDTSLEGIE SAIKVCCKFS CRTQRKAFIS ALLTFTHLTN LREIEYKSLK SIIALTRVAL
EEGDHLETSW YEVLRCISLL SKLQILAESP WTSLLNDRNG NHAAPKAPNT SLEGQGRSSL
QPQWERAKLE RQNAEIIAKY IDEVEVHRLF SRSNYLKDAA VVSLVEALCL VSAEELAENP
PRIFSLQKLV EVTDTNIGRL RYVWSKMWTN VSRHFVKVAL SSNELEPMYV VDHLRQLATK
FLARGELGDF NFQKGVLQPF EAIASRTQST KLKELLVASL GQMVEAQAQN LRSGWGTLIE
ALAHCVQHDT NPDVVSSSAI VLQNITLCHL HLLTTSDLVK IVRAWAVVAR SAFSDDFAHS
AVWFVRYVTI ALALQADSNS SCEGVQHSHA SQCGTSSNGE KEIHVDESHS HAIKENNKSH
SLLLKEEIKA LALRAAFPVD GDDNNKVERG RARTKENMQL FPVAVGALAS LLVHRSISGE
AMEAMLFVMT DHRAVFTPEE WWHTVGSGVA PALDFLLQQC RFSNETERDV WLSLFKRAVT
NVVQFVGYNL DGNPLPVDHV LFLFRVFVGR ACCGSHDEAT ELGLQGARQM LDLFKEHAVV
DELLWNGMVE YIQEIGDILL GALDSIWRHP MDPTQQDTLK PTLLALLQYV KWNRDAALTP
QLTTLCRTKA VKVLLKTLQR FMCLMRTSVS FRDSVTEKRD VFDLALFIAL ECSLCNAILD
AERRYGEILE NESNTLWMLI IGQFLAVTGK TSNVSREEAS SLRGIIRELL DAMLEAPQRV
MMARCRICMP FLCQLIALSD DVFAESLANL FLRYHTATVQ NI
//
