ID Q4FLD5_PELUB Unreviewed; 288 AA.
AC Q4FLD5;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:AAZ22003.1};
DE EC=1.1.1.31 {ECO:0000313|EMBL:AAZ22003.1};
GN Name=mmsB {ECO:0000313|EMBL:AAZ22003.1};
GN OrderedLocusNames=SAR11_1196 {ECO:0000313|EMBL:AAZ22003.1};
OS Pelagibacter ubique (strain HTCC1062).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Candidatus Pelagibacterales;
OC Candidatus Pelagibacteraceae; Pelagibacter.
OX NCBI_TaxID=335992 {ECO:0000313|EMBL:AAZ22003.1, ECO:0000313|Proteomes:UP000002528};
RN [1] {ECO:0000313|EMBL:AAZ22003.1, ECO:0000313|Proteomes:UP000002528}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC1062 {ECO:0000313|EMBL:AAZ22003.1,
RC ECO:0000313|Proteomes:UP000002528};
RX PubMed=16109880; DOI=10.1126/science.1114057;
RA Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D.,
RA Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M.,
RA Carrington J.C., Mathur E.J.;
RT "Genome streamlining in a cosmopolitan oceanic bacterium.";
RL Science 309:1242-1245(2005).
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DR EMBL; CP000084; AAZ22003.1; -; Genomic_DNA.
DR RefSeq; WP_011282212.1; NC_007205.1.
DR AlphaFoldDB; Q4FLD5; -.
DR STRING; 335992.SAR11_1196; -.
DR GeneID; 83857539; -.
DR KEGG; pub:SAR11_1196; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_5; -.
DR OrthoDB; 9812907at2; -.
DR Proteomes; UP000002528; Chromosome.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:AAZ22003.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002528}.
FT DOMAIN 3..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 288 AA; 31275 MW; 3F186CD80A7AF777 CRC64;
MSNVAFIGLG VMGYPMAGYI SKAGHNVTVY NRTAAKADKW VAEYKGSKAD TPAKAAEDAD
FVFTCVGNDN DLREVTFGDN GIFKTIKKGS VYIDNTTASA TIAREIYEHS LKSEFGFLDA
PVSGGQAGAE NGALTVMIGG DQANFDKAKD IIDCYSKKMK LLGGAGNGQL AKMVNQICIA
GLVQGLSEAI NFGKKAGLNM EDVIEVISKG AAQSWQMENR YKTMIDDQFE FGFAVDWMRK
DLKIAMDEAK NNGSQLPVTE IVDKYYGEVQ EMGGNRWDTS SLIRRLSK
//
