ID Q4FLP3_PELUB Unreviewed; 304 AA.
AC Q4FLP3;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Ribosomal large subunit pseudouridine synthase C {ECO:0000313|EMBL:AAZ21895.1};
DE EC=4.2.1.70 {ECO:0000313|EMBL:AAZ21895.1};
GN Name=rluC {ECO:0000313|EMBL:AAZ21895.1};
GN OrderedLocusNames=SAR11_1091 {ECO:0000313|EMBL:AAZ21895.1};
OS Pelagibacter ubique (strain HTCC1062).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Candidatus Pelagibacterales;
OC Candidatus Pelagibacteraceae; Pelagibacter.
OX NCBI_TaxID=335992 {ECO:0000313|EMBL:AAZ21895.1, ECO:0000313|Proteomes:UP000002528};
RN [1] {ECO:0000313|EMBL:AAZ21895.1, ECO:0000313|Proteomes:UP000002528}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC1062 {ECO:0000313|EMBL:AAZ21895.1,
RC ECO:0000313|Proteomes:UP000002528};
RX PubMed=16109880; DOI=10.1126/science.1114057;
RA Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D.,
RA Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M.,
RA Carrington J.C., Mathur E.J.;
RT "Genome streamlining in a cosmopolitan oceanic bacterium.";
RL Science 309:1242-1245(2005).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000256|ARBA:ARBA00010876}.
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DR EMBL; CP000084; AAZ21895.1; -; Genomic_DNA.
DR RefSeq; WP_006996836.1; NC_007205.1.
DR AlphaFoldDB; Q4FLP3; -.
DR STRING; 335992.SAR11_1091; -.
DR GeneID; 83857429; -.
DR KEGG; pub:SAR11_1091; -.
DR eggNOG; COG0564; Bacteria.
DR HOGENOM; CLU_016902_1_2_5; -.
DR OrthoDB; 9807829at2; -.
DR Proteomes; UP000002528; Chromosome.
DR GO; GO:0004730; F:pseudouridylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AAZ21895.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002528};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT DOMAIN 14..85
FT /note="RNA-binding S4"
FT /evidence="ECO:0000259|SMART:SM00363"
SQ SEQUENCE 304 AA; 35422 MW; F56D99B6F443D62F CRC64;
MKKSFNVDST FNDMRIDRWI RNNLGNYPQG LIEKSLKSGK VKINNKKIKS SHKVKTGDTI
DLFNFDFKET IVQKTIKFVP SEEVIKENEE LIIDNNDDFI VLNKSSGISV QGGTKSKKNL
VDIFARSEIF QDTKPFSVHR LDKDTSGVFI MAKHRQSAQL LTSLFRLRKV HKTYLAICHG
ELQKDSGEWN DDLTRYDNDR EVVEKARTLY KVLDKNSICS LVEMKPITGR KHQLRKQLYA
VGCPIYGDQK YKFSNTDKAI NKNLMLHSYQ IKFMINDKKY TYTALLPDYF KKLLKTKRLR
FPNS
//
