GenomeNet

Database: UniProt
Entry: Q4G063
LinkDB: Q4G063
Original site: Q4G063 
ID   CREL2_RAT               Reviewed;         349 AA.
AC   Q4G063;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   16-JAN-2019, entry version 96.
DE   RecName: Full=Cysteine-rich with EGF-like domain protein 2;
DE   Flags: Precursor;
GN   Name=Creld2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=16238698; DOI=10.1111/j.1471-4159.2005.03473.x;
RA   Ortiz J.A., Castillo M., Dominguez del Toro E., Mulet J., Gerber S.,
RA   Valor L.M., Sala S., Sala F., Gutierrez L.M., Criado M.;
RT   "The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts
RT   with the large cytoplasmic domain of human neuronal nicotinic
RT   acetylcholine receptor alpha4 and beta2 subunits.";
RL   J. Neurochem. 95:1585-1596(2005).
CC   -!- FUNCTION: May regulate transport of alpha4-beta2 neuronal
CC       acetylcholine receptor. {ECO:0000250}.
CC   -!- SUBUNIT: May interact with CHRNA4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Broadly expressed in brain (at protein level).
CC       {ECO:0000269|PubMed:16238698}.
CC   -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
DR   EMBL; BC098722; AAH98722.1; -; mRNA.
DR   RefSeq; NP_001032285.1; NM_001037208.1.
DR   UniGene; Rn.19198; -.
DR   ProteinModelPortal; Q4G063; -.
DR   SMR; Q4G063; -.
DR   STRING; 10116.ENSRNOP00000006357; -.
DR   iPTMnet; Q4G063; -.
DR   PhosphoSitePlus; Q4G063; -.
DR   PaxDb; Q4G063; -.
DR   PRIDE; Q4G063; -.
DR   Ensembl; ENSRNOT00000006357; ENSRNOP00000006357; ENSRNOG00000004659.
DR   GeneID; 362978; -.
DR   KEGG; rno:362978; -.
DR   CTD; 79174; -.
DR   RGD; 1310614; Creld2.
DR   eggNOG; KOG4260; Eukaryota.
DR   eggNOG; ENOG41107X2; LUCA.
DR   GeneTree; ENSGT00940000160071; -.
DR   HOGENOM; HOG000004778; -.
DR   HOVERGEN; HBG081344; -.
DR   InParanoid; Q4G063; -.
DR   OMA; CVGCTGK; -.
DR   OrthoDB; 883628at2759; -.
DR   PhylomeDB; Q4G063; -.
DR   TreeFam; TF316507; -.
DR   PRO; PR:Q4G063; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000004659; Expressed in 9 organ(s), highest expression level in testis.
DR   Genevisible; Q4G063; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00064; FU; 2.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; Laminin_EGF.
DR   Pfam; PF11938; DUF3456; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   1: Evidence at protein level;
KW   Calcium; Complete proteome; Disulfide bond; EGF-like domain;
KW   Endoplasmic reticulum; Glycoprotein; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23    349       Cysteine-rich with EGF-like domain
FT                                protein 2.
FT                                /FTId=PRO_0000256247.
FT   DOMAIN      133    175       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      190    237       FU 1.
FT   REPEAT      250    297       FU 2.
FT   DOMAIN      287    328       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CARBOHYD    187    187       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    248    248       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    137    151       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    145    163       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    165    174       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    291    305       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    298    314       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    316    327       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   349 AA;  38251 MW;  5E8ABE53CB9F8850 CRC64;
     MHLLLAAGFG LLLLLLPPPA ASKKPTQCQR CRTLVDKFNQ GMANTARKNF GGGNTAWEEK
     TLSKYEFSEI RLLEIMEGLC DSSDFECNQL LEQQEEQLEA WWQSLKKDYP NLFEWFCVRT
     LKACCLPGTY GPDCKECQGG SERPCSGNGY CSGDGSRQGD GSCQCHAGYK GPLCIDCMDG
     YFSLQRNETH SICLACDESC KTCSGPSNKD CVQCEVGWAR VEDACVDVDE CAAETPPCSE
     AQYCENVNGS YICEECDSTC VGCTGKGPAN CKECIAGYTK QSGQCADIDE CSLEEKACKR
     RNENCYNVPG SFVCVCPDGF EETEDACVQT AQSEVTEENP TQPLSHEDL
//
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