ID Q4GZF1_TRYB2 Unreviewed; 516 AA.
AC Q4GZF1;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Phosphate transporter {ECO:0000256|RuleBase:RU363058};
GN ORFNames=TB927.1.580 {ECO:0000313|EMBL:CAJ15952.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:CAJ15952.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:CAJ15952.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:CAJ15952.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=12907729; DOI=10.1093/nar/gkg674;
RA Hall N., Berriman M., Lennard N.J., Harris B.R., Hertz-Fowler C.,
RA Bart-Delabesse E.N., Gerrare C.S., Atkin R.J., Barron A.J., Bowman S.,
RA Bray-Allen S.P., Bringaud F., Clark L.N., Corton C.H., Cronin A.,
RA Davies R., Doggett J., Fraser A., Gruter E., Hall S., Harper A.D.,
RA Kay M.P., Leech V., Mayes R., Price C., Quail M.A., Rabbinowitch E.,
RA Reitter C., Rutherford K., Sasse J., Sharp S., Shownkeen R., Macleod A.,
RA Taylor S., Tweedie A., Turner C.M.R., Tait A., Gull K., Barrell B.,
RA Melville S.E.;
RT "The DNA sequence of chromosome I of an African trypanosome: gene content,
RT chromosome organisation, recombination and polymorphism.";
RL Nucleic Acids Res. 31:4864-4873(2003).
RN [2] {ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- FUNCTION: Sodium-phosphate symporter. {ECO:0000256|RuleBase:RU363058}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363058}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363058}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000256|RuleBase:RU363058}.
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DR EMBL; AL929603; CAJ15952.1; -; Genomic_DNA.
DR RefSeq; XP_001218761.1; XM_001218760.1.
DR AlphaFoldDB; Q4GZF1; -.
DR STRING; 185431.Q4GZF1; -.
DR PaxDb; 5691-CAJ15952; -.
DR GeneID; 4357155; -.
DR KEGG; tbr:TB927.1.580; -.
DR VEuPathDB; TriTrypDB:Tb927.1.580; -.
DR eggNOG; KOG2493; Eukaryota.
DR InParanoid; Q4GZF1; -.
DR OMA; MQAFCIA; -.
DR OrthoDB; 125333at2759; -.
DR Proteomes; UP000008524; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PHOSPHATE TRANSPORTER; 1.
DR PANTHER; PTHR11101:SF96; PHOSPHATE TRANSPORTER; 1.
DR Pfam; PF01384; PHO4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363058};
KW Phosphate transport {ECO:0000256|RuleBase:RU363058};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363058};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363058};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363058}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 41..63
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 83..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 116..137
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 190..211
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 223..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 396..421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 441..474
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 486..509
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT REGION 296..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 54493 MW; 9A8D4A46D686EB2D CRC64;
MVHPYLWVII VGGIVSFLTG CGVGMNDLAN SFGTTYGSRV LNLWQIVILA SICEFVGAVS
LGSEVTSTIS GGIANPMTFA NEPYVLMYGM MCALSATFIW LLFATMMSLP VSSTHSIAGA
IIGFALVYGG FGAVSFAKKI DEFPYVTGVA PIIASWFISP MFAGAVAASL YALLRLVVLR
PANSVNRALF ALPLIVGVTF FLESFFVLFK GAKARLHWGP AKASWVAALI GLGAASISAA
CIPLLRRRVR LITERAERER AETGMNTAPE ISGDAGAISE NAAGVGAAVE GPVDTANRIV
PPSSEPTSDS PTAKENPANN ASGLTTPGVV DEALKFDVQI YDERVEYVFR YLQVFTAACA
SFAHGANDVS NAIAPFSAMY SIYINQQVVE ENDVPLWILV LGGAGLVVGL ATLGVGIMRL
LGERITKITP SRGFSAELSV ALVVSLCSAF GIPVSSTHCI TGAVVAISIM DCGFRKVRWM
MVGKMYLGWI FTLLITAAIS ALLFAQGIYA PSLTSQ
//
