ID Q4H2T4_CIOIN Unreviewed; 527 AA.
AC Q4H2T4; A0A1W2VQ81; F6USQ5;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
GN Name=Ci-Smad4 {ECO:0000313|EMBL:BAE06693.1};
GN Synonyms=smad4 {ECO:0000313|Ensembl:ENSCINP00000011529.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|EMBL:BAE06693.1};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|EMBL:BAE06693.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12736827; DOI=10.1007/s00427-003-0330-z;
RA Satou Y., Satoh N.;
RT "Genomewide surveys of developmentally relevant genes in Ciona
RT intestinalis.";
RL Dev. Genes Evol. 213:211-212(2003).
RN [3] {ECO:0000313|EMBL:BAE06693.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15269171; DOI=10.1242/dev.01270;
RA Imai K.S., Hino K., Yagi K., Satoh N., Satou Y.;
RT "Gene expression profiles of transcription factors and signaling molecules
RT in the ascidian embryo: towards a comprehensive understanding of gene
RT networks.";
RL Development 131:4047-4058(2004).
RN [4] {ECO:0000313|EMBL:BAE06693.1}
RP NUCLEOTIDE SEQUENCE.
RA Satou Y.;
RT "Expressed genes in Ciona intestinalis.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSCINP00000011529.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR EMBL; EAAA01002273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB210688; BAE06693.1; -; mRNA.
DR RefSeq; NP_001071944.1; NM_001078476.1.
DR STRING; 7719.ENSCINP00000011529; -.
DR Ensembl; ENSCINT00000011529.3; ENSCINP00000011529.3; ENSCING00000005559.3.
DR GeneID; 778905; -.
DR KEGG; cin:778905; -.
DR CTD; 4089; -.
DR GeneTree; ENSGT00940000168575; -.
DR HOGENOM; CLU_026736_1_1_1; -.
DR OMA; RMCILIS; -.
DR OrthoDB; 5395671at2759; -.
DR TreeFam; TF314923; -.
DR Proteomes; UP000008144; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0071144; C:heteromeric SMAD protein complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0070411; F:I-SMAD binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IBA:GO_Central.
DR CDD; cd10492; MH1_SMAD_4; 1.
DR CDD; cd10498; MH2_SMAD_4; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF45; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 13..137
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 295..527
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT COILED 28..59
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 527 AA; 57315 MW; 1402D8657066A8F3 CRC64;
MQNPTTSNDA CLSIVHSLMC HRQGGESESF AKRAIESLVK KLKEKKDELE SLITAITTSG
AHPSKCVTIQ RTLDGRLQVA GRKGFPHVIY ARLWRWPDLH KNELKHLKVC KFAFDLKCDS
VCINPYHYDR VVSPGIDLSG LTLQHTPAAA PLVSNDYQDL KITDVQGNWM NQGKAEAMPL
GPVQHQASEE YTSTSKAGTS NGISNGPVSG TMQYTPGASS FSTPSSSAPV NPNQAIGSAS
QQLIQYSQRN QHMSWQAGST AKYTPEMSTP MTAPYYSPND VPYLPVSTHP GPEFWCSITA
YEMDVQVGET FKVPSSCPAV TVDGYVDPSG GNRFCLGQLS NVHRTEASEK ARLHIGKGVQ
LVCHGEGDVW VKCLSDHAVF VQSYYLDREA GRSPGDAVHK IYPNAYIKVF DLRQCHRQMQ
QQANTASAAA NAQAAAVSGN IPGPGSVGGI APAIGLPGLS AAAGIGVDDL RRLCILRMSF
VKGWGPDYPR QDIKQTPCWI EIQLHRALQL LDEVLHTMPI GEPHSHD
//
