ID Q4H306_CIOIN Unreviewed; 190 AA.
AC Q4H306;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
DE Flags: Fragment;
GN Name=Ci-Orphan Wnt d {ECO:0000313|EMBL:BAE06621.1};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|EMBL:BAE06621.1};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|EMBL:BAE06621.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12736827; DOI=10.1007/s00427-003-0330-z;
RA Satou Y., Satoh N.;
RT "Genomewide surveys of developmentally relevant genes in Ciona
RT intestinalis.";
RL Dev. Genes Evol. 213:211-212(2003).
RN [3] {ECO:0000313|EMBL:BAE06621.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15269171; DOI=10.1242/dev.01270;
RA Imai K.S., Hino K., Yagi K., Satoh N., Satou Y.;
RT "Gene expression profiles of transcription factors and signaling molecules
RT in the ascidian embryo: towards a comprehensive understanding of gene
RT networks.";
RL Development 131:4047-4058(2004).
RN [4] {ECO:0000313|EMBL:BAE06621.1}
RP NUCLEOTIDE SEQUENCE.
RA Satou Y.;
RT "Expressed genes in Ciona intestinalis.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSCINP00000033077.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; EAAA01002133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB210616; BAE06621.1; -; mRNA.
DR STRING; 7719.ENSCINP00000033077; -.
DR Ensembl; ENSCINT00000036055.1; ENSCINP00000033077.1; ENSCING00000019801.1.
DR GeneTree; ENSGT00940000168893; -.
DR HOGENOM; CLU_033039_3_1_1; -.
DR OMA; CHRIVSH; -.
DR Proteomes; UP000008144; Chromosome 5.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR043158; Wnt_C.
DR PANTHER; PTHR12027:SF98; PROTEIN WNT; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAE06621.1"
SQ SEQUENCE 190 AA; 21952 MW; 00A4746EED27BF2A CRC64;
KWFEPNSKRR KKRLMTSSDK LNLHNANVGR RVYEDLTALN CVCSGLSGSC ALRTCWKRHP
DLRVVAAELK KLYKKARPVV LATQTRNPTR YKITTGSGRV RKLFKKELAY FNRTPDLCEP
DEITGSLGTK KRECKLRSND AGDCRRLCCR RGFYDVTKEI TYTCNCQFHF CCRVTCQVCR
RSETLHICNG
//
