ID Q4H308_CIOIN Unreviewed; 510 AA.
AC Q4H308; A0A1W2VRX6; F6W410;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN Name=Ci-Orphan Wnt b {ECO:0000313|EMBL:BAE06619.1};
GN Synonyms=LOC778720 {ECO:0000313|Ensembl:ENSCINP00000004395.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|EMBL:BAE06619.1};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|EMBL:BAE06619.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12736827; DOI=10.1007/s00427-003-0330-z;
RA Satou Y., Satoh N.;
RT "Genomewide surveys of developmentally relevant genes in Ciona
RT intestinalis.";
RL Dev. Genes Evol. 213:211-212(2003).
RN [3] {ECO:0000313|EMBL:BAE06619.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15269171; DOI=10.1242/dev.01270;
RA Imai K.S., Hino K., Yagi K., Satoh N., Satou Y.;
RT "Gene expression profiles of transcription factors and signaling molecules
RT in the ascidian embryo: towards a comprehensive understanding of gene
RT networks.";
RL Development 131:4047-4058(2004).
RN [4] {ECO:0000313|EMBL:BAE06619.1}
RP NUCLEOTIDE SEQUENCE.
RA Satou Y.;
RT "Expressed genes in Ciona intestinalis.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSCINP00000004395.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; EAAA01001006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB210614; BAE06619.1; -; mRNA.
DR RefSeq; NP_001071794.1; NM_001078326.1.
DR STRING; 7719.ENSCINP00000004395; -.
DR Ensembl; ENSCINT00000004395.3; ENSCINP00000004395.3; ENSCING00000002145.3.
DR GeneID; 778720; -.
DR KEGG; cin:778720; -.
DR GeneTree; ENSGT00940000171600; -.
DR HOGENOM; CLU_033039_1_4_1; -.
DR OrthoDB; 2874082at2759; -.
DR TreeFam; TF105310; -.
DR Proteomes; UP000008144; Chromosome 12.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR043158; Wnt_C.
DR PANTHER; PTHR12027:SF37; PROTEIN WNT; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT REGION 367..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..432
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 58060 MW; 2B9E855E5A7F695A CRC64;
MELPLYRYVT AMPHHLSLLV IVFLDICTTS GNSWLFFGKL HASSTSSIEQ ICLQMPLEPE
QKQYCKNHTK IMERIRDGTE MAMKECQYQF RNERWNCSSA DESQGFGKVL KRGTREAAFV
GAITSAAVAH EVTRACSRGE LTECSCDGQK RMGSYRDHRG RFEWAGCSDD VQFGMSVAKI
FVNTKDNALH DARAIMNVHN NRAGRKTVKS FMKRFCKCHG ATDTCPLRTC WDALDSFRLS
GNQLKRKYDG ASRVTVKQGS RKMTLHTTVS SHKSPTKRDL VYLEDSPNYC VRNEATGSLG
TSGRECNLSS KGIDGCSLLC CGRGHDTSSV TRTRINCACV FHWCCEVRCT NCTNTYDIYT
CKPEPMQEDP TQQTISSTTT DVSSAAPTRN SGTTLSTSTK GRKSGRRRNK KTRRRKGRRK
GRRGRKQKNT TGPVRAKRNI PEHEEDDVDI DVMDLNEEVE DFRLDFDEDS LEKYRGGTWD
KNESRELYWF SKWWVTMQRF LYHDRSAVTG
//
