GenomeNet

Database: UniProt
Entry: Q4HZ42
LinkDB: Q4HZ42
Original site: Q4HZ42 
ID   DBP10_GIBZE             Reviewed;         897 AA.
AC   Q4HZ42; A0A0E0SEY3; V6RPJ8;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 1.
DT   31-JUL-2019, entry version 94.
DE   RecName: Full=ATP-dependent RNA helicase DBP10;
DE            EC=3.6.4.13;
GN   Name=DBP10; ORFNames=FGRRES_09766, FGSG_09766;
OS   Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
OS   (Wheat head blight fungus) (Fusarium graminearum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Fusarium.
OX   NCBI_TaxID=229533;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084;
RX   PubMed=17823352; DOI=10.1126/science.1143708;
RA   Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G.,
RA   Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G.,
RA   Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D.,
RA   Gale L.R., Gnerre S., Goswami R.S., Hammond-Kosack K., Harris L.J.,
RA   Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G.,
RA   Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G.,
RA   Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W.,
RA   Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA   Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT   "The Fusarium graminearum genome reveals a link between localized
RT   polymorphism and pathogen specialization.";
RL   Science 317:1400-1402(2007).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084;
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J.,
RA   Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M.,
RA   Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C.,
RA   Xie X., Xu J.-R., Antoniw J., Baker S.E., Bluhm B.H., Breakspear A.,
RA   Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M.,
RA   Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S.,
RA   Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K.,
RA   Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M.,
RA   Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y.,
RA   Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S.,
RA   Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O.,
RA   Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C.,
RA   Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084;
RX   PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA   King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA   Hammond-Kosack K.E.;
RT   "The completed genome sequence of the pathogenic ascomycete fungus
RT   Fusarium graminearum.";
RL   BMC Genomics 16:544-544(2015).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX54/DBP10
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS231668; ESU16386.1; -; Genomic_DNA.
DR   EMBL; HG970335; CEF84996.1; -; Genomic_DNA.
DR   RefSeq; XP_011327930.1; XM_011329628.1.
DR   SMR; Q4HZ42; -.
DR   STRING; 5518.FGSG_09766P0; -.
DR   PRIDE; Q4HZ42; -.
DR   EnsemblFungi; ESU16386; ESU16386; FGSG_09766.
DR   GeneID; 23556702; -.
DR   KEGG; fgr:FGSG_09766; -.
DR   EuPathDB; FungiDB:FGRAMPH1_01G26333; -.
DR   eggNOG; KOG0337; Eukaryota.
DR   eggNOG; ENOG410XQE5; LUCA.
DR   InParanoid; Q4HZ42; -.
DR   KO; K14808; -.
DR   Proteomes; UP000070720; Chromosome 4.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR012541; DBP10_C.
DR   InterPro; IPR033517; DDX54/DBP10.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   PANTHER; PTHR24031:SF292; PTHR24031:SF292; 1.
DR   Pfam; PF08147; DBP10CT; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM01123; DBP10CT; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    897       ATP-dependent RNA helicase DBP10.
FT                                /FTId=PRO_0000232316.
FT   DOMAIN      113    285       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      333    492       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     126    133       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        82    110       Q motif.
FT   MOTIF       233    236       DEAD box.
SQ   SEQUENCE   897 AA;  99105 MW;  EA39B41784404FF2 CRC64;
     MPRRGASPTP SEGEIDIFGS LYPGETDNAN GGNGGDDFDF DGLLNNPEPG NDDTDEAFIA
     LQQAASFRKA TNLKGRTVKK GGGFQAMGLN NNLLKAITRK GFSVPTPIQR KAIPLILDRK
     DLVGMARTGS GKTAAFVIPM IEKLRAHSAR FGTRALIMSP SRELAIQTLK VVKEFSRGTD
     LKCVLLVGGD SLEEQFGYMA ANPDIVIATP GRFLHLKVEM SLDLSSIKYV VFDEADRLFE
     MGFAAQLTEI LHALPPSRQS LLFSATLPAS LVEFARAGLQ DPSLVRLDAE QKVSPDLESA
     FFAVKGAEKE GSLLHILHDV IKMPVGSPEG VNNDSEKGSK KRKRGADGGS GKPTEHSTII
     FTATKHHVEY LANLLIYAGF AVSYVYGSLD QTARRIQVED FRMGKTNILV VTDVAARGID
     IPVLANVINF DFPPQPKVFV HRVGRTARAG QRGWSYSLVR DTDAPYLIDL QLFLGKKLVV
     GQETKNPSFS EDVVVGALKR DPVEGHVEWF NKSLHESEDI NALRGVAVKA EKLYLRTRNS
     AASQSAKRSK ELVGSQGWTQ LHPLFGEDVD GAEQARVDML ARISGFRPQE TIFEIGGRRD
     KGTTEAAEVM KQLRKRITPR RQTEAKADDD FEGIGDDIPA AAEAGADSDE EEVVMDEMDV
     DEESDDGLEV TVTNTNSKKG RTDWRDSEVF MSYTPRTFNA AEERGYGVSS GGQDPSNFVE
     AARGVTMDLT NDENAKSFGE PTRSKMRWDK KSRKYVSREN DEDGSKGAKM IRGESGVKIA
     ASFQSGRFDK WKRANRLGKL PHVGEQVRPG SASHAANLPS GVRYKHKQER APKEADKYRD
     DFEVRKKRVD EAREKRVGRF RDGMGSKKEL KGREDIRKAR IEKEKKRLKN ARPTRRK
//
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