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Database: UniProt
Entry: Q4I8C9
LinkDB: Q4I8C9
Original site: Q4I8C9 
ID   SET9_GIBZE              Reviewed;         662 AA.
AC   Q4I8C9; A0A098DNJ7; A0A0E0SAI3; A0A1C3YKX8; V6RDC8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 1.
DT   10-APR-2019, entry version 76.
DE   RecName: Full=Histone-lysine N-methyltransferase SET9;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain protein 9;
GN   Name=SET9; ORFNames=FGRAMPH1_01T22513, FGRRES_06529_M, FGSG_06529;
OS   Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
OS   (Wheat head blight fungus) (Fusarium graminearum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Fusarium.
OX   NCBI_TaxID=229533;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084;
RX   PubMed=17823352; DOI=10.1126/science.1143708;
RA   Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G.,
RA   Di Pietro A., Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G.,
RA   Antoniw J., Baldwin T., Calvo S.E., Chang Y.-L., DeCaprio D.,
RA   Gale L.R., Gnerre S., Goswami R.S., Hammond-Kosack K., Harris L.J.,
RA   Hilburn K., Kennell J.C., Kroken S., Magnuson J.K., Mannhaupt G.,
RA   Mauceli E.W., Mewes H.-W., Mitterbauer R., Muehlbauer G.,
RA   Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T., Qi W.,
RA   Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA   Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT   "The Fusarium graminearum genome reveals a link between localized
RT   polymorphism and pathogen specialization.";
RL   Science 317:1400-1402(2007).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084;
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J.,
RA   Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M.,
RA   Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C.,
RA   Xie X., Xu J.-R., Antoniw J., Baker S.E., Bluhm B.H., Breakspear A.,
RA   Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M.,
RA   Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S.,
RA   Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K.,
RA   Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M.,
RA   Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y.,
RA   Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S.,
RA   Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O.,
RA   Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C.,
RA   Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084;
RX   PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA   King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA   Hammond-Kosack K.E.;
RT   "The completed genome sequence of the pathogenic ascomycete fungus
RT   Fusarium graminearum.";
RL   BMC Genomics 16:544-544(2015).
CC   -!- FUNCTION: Histone methyltransferase that specifically methylates
CC       'Lys-20' of histone H4. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00900};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00900}.
DR   EMBL; DS231666; ESU12633.1; -; Genomic_DNA.
DR   EMBL; HG970335; SCB65068.1; -; Genomic_DNA.
DR   RefSeq; XP_011326140.1; XM_011327838.1.
DR   ProteinModelPortal; Q4I8C9; -.
DR   SMR; Q4I8C9; -.
DR   STRING; 5518.FGSG_06529P0; -.
DR   EnsemblFungi; ESU12633; ESU12633; FGSG_06529.
DR   GeneID; 23553658; -.
DR   KEGG; fgr:FGSG_06529; -.
DR   EuPathDB; FungiDB:FGRAMPH1_01G22513; -.
DR   eggNOG; KOG2589; Eukaryota.
DR   eggNOG; ENOG410XPH8; LUCA.
DR   InParanoid; Q4I8C9; -.
DR   KO; K11429; -.
DR   Proteomes; UP000070720; Chromosome 4.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:InterPro.
DR   InterPro; IPR025783; Hist-Lys_N-MeTrfase_SET9.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    662       Histone-lysine N-methyltransferase SET9.
FT                                /FTId=PRO_0000281804.
FT   DOMAIN      115    229       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   662 AA;  74100 MW;  BD446F10FA6AB134 CRC64;
     MAPSQTANKK PRMTLAQVSA YDDILTDALV DHVFYWTTVP KNRTSYHPSR GVKEEEISKI
     LQEEVVLKKD LDSAEKRLLT TNGLKRFHNG LKTDKEKDDF RKHLRRYVQI YLPDCPWEVS
     STNRYTIVSH EAAVTARRAI RRNEAIKYLS GVQVVITPEE EMAISSQKKD FSIVVSSRSK
     CTSLFMGPAR FANHDCDANA KLMRTSHAGI EIVATRPIDA GEEITVTYGD NYFGENNCEC
     LCKTCEDLLR NAWEPEEGTV PVQTGIGQSL SDGYSLRRRR RDDSISGSSR TPSVTPDMRP
     RITKANSRGS LLARDTSSVR SPSIDQTSRK RTHDVLATPP KTPAKRQKLG VQPIVSDSSS
     RGTSVTASES SGAVETDVTS PEKETPEPMQ TPLKGASKKQ NNEQSRLAPV SPQSTEGSRS
     PQQKNGALSS NRSSLDTMSI QAILNDPLES EVESEPESKM KKVTVVPPPV EPVAPIATSI
     EAVEEGQAAD AEQSKRKKQP RRVHKEDTPP ARVRTPGDYL LTPLLLSEPE MAWIQCTNCD
     EYFVQQNAYF TRASCPRCER HSKLYGYIWP KTDKAGPNDK EERILDHRTI HRFLDPDNER
     RVRNRKSFGA SKTNTEEAED VERGRKRFGT AGLMGRNAST TEDSGHRRSG RLRRVNSRFL
     DP
//
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