ID Q4JCD6_SULAC Unreviewed; 523 AA.
AC Q4JCD6;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Conserved protein {ECO:0000313|EMBL:AAY79543.1};
GN OrderedLocusNames=Saci_0119 {ECO:0000313|EMBL:AAY79543.1};
OS Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS 15157 / NCIMB 11770).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=330779 {ECO:0000313|EMBL:AAY79543.1, ECO:0000313|Proteomes:UP000001018};
RN [1] {ECO:0000313|EMBL:AAY79543.1, ECO:0000313|Proteomes:UP000001018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770
RC {ECO:0000313|Proteomes:UP000001018};
RX PubMed=15995215; DOI=10.1128/JB.187.14.4992-4999.2005;
RA Chen L., Brugger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT "The genome of Sulfolobus acidocaldarius, a model organism of the
RT Crenarchaeota.";
RL J. Bacteriol. 187:4992-4999(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; CP000077; AAY79543.1; -; Genomic_DNA.
DR RefSeq; WP_011277044.1; NZ_CP046615.1.
DR AlphaFoldDB; Q4JCD6; -.
DR STRING; 330779.Saci_0119; -.
DR GeneID; 78440473; -.
DR KEGG; sai:Saci_0119; -.
DR PATRIC; fig|330779.12.peg.111; -.
DR eggNOG; arCOG01969; Archaea.
DR HOGENOM; CLU_520355_0_0_2; -.
DR Proteomes; UP000001018; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..357
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 523 AA; 58235 MW; 523D7147FC7C0191 CRC64;
MESQLTLITL TLVIATIFGV ALSRFRISPI PAYLIAGLLG KSFGLDYSSD LFNFLSTLAI
NLVSFNVGIS LDIRELKNIL SKATIIAITE YIVGFTIISI ISLIIGLPFY DTFILTIISV
TTSTTITYKL IQNKIDDKQS GLILAVLSLE DVITFIALGV ILSSNSNIVE IIPTSLASLG
LGYLVSRTII NRSINTSEES VIISSIASVL SFSLLGQIFD IPSTLANFLL GLGASYALKD
TKKVSRILSP LIDFSLIFFF FSAGSYLNLS LSSLYVLVPI SLIMTLVKYL SFSTSYWLTG
SNFLVAFRSG IYMTSLSELG IIVALNAFQQ GIITSLVYNL SAFLVMMSST ITSITVPRER
RIIGLISKTY EKLRIDRIDG ALQRITRVVK LNRNTTSNFI LRFILIGLIT IFSASYLLIF
LVSFARFFIY IAPLISVLVP FLLALLVIEE TRRLSNLGQK RINEIILWII YVFITINFEI
FIVRIISELN YYVIYLGILV SIIVIVIMYQ RLNTFIKELD KSL
//
