ID Q4JTA0_CORJK Unreviewed; 472 AA.
AC Q4JTA0;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN Name=pvdA {ECO:0000313|EMBL:CAI37957.1};
GN OrderedLocusNames=jk1780 {ECO:0000313|EMBL:CAI37957.1};
OS Corynebacterium jeikeium (strain K411).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=306537 {ECO:0000313|EMBL:CAI37957.1, ECO:0000313|Proteomes:UP000000545};
RN [1] {ECO:0000313|EMBL:CAI37957.1, ECO:0000313|Proteomes:UP000000545}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K411 {ECO:0000313|EMBL:CAI37957.1,
RC ECO:0000313|Proteomes:UP000000545};
RX PubMed=15968079; DOI=10.1128/JB.187.13.4671-4682.2005;
RA Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A.,
RA Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F.,
RA Rupp O., Schneiker S., Viehoever P., Puehler A.;
RT "Complete genome sequence and analysis of the multiresistant nosocomial
RT pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the
RT human skin flora.";
RL J. Bacteriol. 187:4671-4682(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005102}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR EMBL; CR931997; CAI37957.1; -; Genomic_DNA.
DR RefSeq; WP_011274124.1; NC_007164.1.
DR AlphaFoldDB; Q4JTA0; -.
DR STRING; 306537.jk1780; -.
DR GeneID; 72411727; -.
DR KEGG; cjk:jk1780; -.
DR PATRIC; fig|306537.10.peg.1805; -.
DR eggNOG; COG3486; Bacteria.
DR HOGENOM; CLU_020931_2_0_11; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000000545; Chromosome.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000545}.
FT REGION 444..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 52581 MW; DC7117A1CAF7E84E CRC64;
MTIIDRQAQT SAERSTHENS VRDIVGIGIG PGNLGLAVAI EEQAPELDAL FVEARPEFNW
HPGMLLEGSN MQISFLKDLV TVRNPQSRFS FINYLHHSDR LIDFINRQTF TPERVEFADY
LRWIADHITV DTQYNTTVTS IETLPELAAD GARFVVHVRR KLGSGESEGQ RAQQSESIRC
RNVVVARGLE AKMPAWAEDS SLDTSRIFHN IDLLPRTKKL LNSGWDIRRA LVIGAGQSAA
EAIRYFHDCP HIDTVTGSLN SYGFIPADDS PFANRVFDPE AVDDFFHAPD AIRNELLIRH
RYTNYACVES ELLDELHDRQ YRESVTGRQR LDIRRTTEVL GARNCSDGSV DVDIRHRVTG
DVVTENFDVV VCATGFRSRG LAGIHADSHG SEEFTVTRDY GAVLNGERVP GLFVQGATEA
THGLGSTLLS NIATRSGELV EAITGQQRTH RAPADEDLRS EQHRDSSHLI AG
//
