ID Q4KBN8_PSEF5 Unreviewed; 415 AA.
AC Q4KBN8;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Multidrug efflux RND transporter, membrane fusion protein MexE {ECO:0000313|EMBL:AAY92509.1};
GN Name=mexE {ECO:0000313|EMBL:AAY92509.1};
GN OrderedLocusNames=PFL_3240 {ECO:0000313|EMBL:AAY92509.1};
OS Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=220664 {ECO:0000313|EMBL:AAY92509.1, ECO:0000313|Proteomes:UP000008540};
RN [1] {ECO:0000313|EMBL:AAY92509.1, ECO:0000313|Proteomes:UP000008540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-477 / NRRL B-23932 / Pf-5
RC {ECO:0000313|Proteomes:UP000008540};
RX PubMed=15980861; DOI=10.1038/nbt1110;
RA Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.,
RA Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J.,
RA Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W., Nelson W.C.,
RA Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S.III.,
RA Thomashow L.S., Loper J.E.;
RT "Complete genome sequence of the plant commensal Pseudomonas fluorescens
RT Pf-5.";
RL Nat. Biotechnol. 23:873-878(2005).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP000076; AAY92509.1; -; Genomic_DNA.
DR RefSeq; WP_011061523.1; NC_004129.6.
DR AlphaFoldDB; Q4KBN8; -.
DR STRING; 220664.PFL_3240; -.
DR GeneID; 57476257; -.
DR KEGG; pfl:PFL_3240; -.
DR PATRIC; fig|220664.5.peg.3306; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_1_6; -.
DR Proteomes; UP000008540; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF10; HLYD FAMILY SECRETION PROTEIN; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..415
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004239699"
FT DOMAIN 62..287
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 415 AA; 44474 MW; AA1D0B98EDE359F0 CRC64;
MDQSVKLLRF PLAVLAVLVM SACGKAPETA SAPPAAKVSV AKVLEQPVNE WDEFTGRLEA
PETVEIRPRV SGQIDQVAFT EGALVKKGDL LFQIDPRPFQ AEVRRLEAQL QQARATATRS
ANEAQRGQRL LTSNAISAEL ADTRTSAAQE ARAGVDAIQA QLDVAKLNLS FTRVVAPISG
RVSRAQITAG NLVTADVTPL TSLVSTDKVY AYFDADERVY LKYTQLARQG QRGQTTPVYL
GLSNEEGHPH LGQMNFVDNQ VNPKTGTIRG RAVFDNSDGS YTPGLYARLK LVGSGTYSAM
LINDEAVGTD LGKKFVLVMD ADNKPAYRAV ELGPKIEGLR IVRNGLSKDD TIIVKGLQRA
RPGAPVTPEV IPMASKETLA ALAQQRQALE ASNLPQVTPA KAAPAVKLAA ATPRG
//
