ID   VRAB_STAHJ              Reviewed;         381 AA.
AC   Q4L3Q1;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   27-MAR-2024, entry version 117.
DE   RecName: Full=Putative acetyl-CoA C-acetyltransferase VraB;
DE            EC=2.3.1.-;
GN   Name=vraB; OrderedLocusNames=SH2417;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP006716; BAE05726.1; -; Genomic_DNA.
DR   RefSeq; WP_011276672.1; NC_007168.1.
DR   AlphaFoldDB; Q4L3Q1; -.
DR   SMR; Q4L3Q1; -.
DR   GeneID; 58061554; -.
DR   KEGG; sha:SH2417; -.
DR   eggNOG; COG0183; Bacteria.
DR   HOGENOM; CLU_031026_2_1_9; -.
DR   OrthoDB; 9764892at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR   PANTHER; PTHR43853:SF3; ACETYL-COA C-ACETYLTRANSFERASE YHFS-RELATED; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Transferase.
FT   CHAIN           1..381
FT                   /note="Putative acetyl-CoA C-acetyltransferase VraB"
FT                   /id="PRO_0000206434"
FT   ACT_SITE        86
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        338
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   381 AA;  41546 MW;  0D5B327B3A20C4DD CRC64;
     MKEAVVIWAK RTPFGKYGGA LRHLEPEALL LPLFQNLKQT FPEVMDQVDD VVLGNVVGNG
     GNVARKSLLE AGLNHRIPGI TLDRQCGSGL ESIIYACRMV QCEAGKVFIA GGVESTSRAP
     WKIKRPQSVY EMQLPQFFER ASFAPEGQDP SMIEAAENVA QHYNISRNDQ DLFAARSHRL
     VATHFNNGDI NREIVPLTIK GALFDRDESL KPNLTEARLH RLRPILPNGT VTVGNSCMKN
     DGAGIALIME KEMAVAMGIK WGMLYRDAVT TGVDPTLLGI GPVPAVSQLL KRQKLNIEDI
     SAIELNEAFS SQVLASINEL HLGLDKVNQW GGAIATGHPY SASGAALVAR LLNLPNWQYG
     IATMGIGGGM GNAVLFEKWR Q
//