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Database: UniProt
Entry: Q4L8G4
LinkDB: Q4L8G4
Original site: Q4L8G4 
ID   Y752_STAHJ              Reviewed;         318 AA.
AC   Q4L8G4;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   13-FEB-2019, entry version 102.
DE   RecName: Full=Putative 2-hydroxyacid dehydrogenase SH0752;
DE            EC=1.1.1.-;
GN   OrderedLocusNames=SH0752;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/JB.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S.,
RA   Lee J.C., Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; AP006716; BAE04061.1; -; Genomic_DNA.
DR   RefSeq; WP_011275076.1; NC_007168.1.
DR   ProteinModelPortal; Q4L8G4; -.
DR   SMR; Q4L8G4; -.
DR   STRING; 279808.SH0752; -.
DR   EnsemblBacteria; BAE04061; BAE04061; SH0752.
DR   GeneID; 24246252; -.
DR   KEGG; sha:SH0752; -.
DR   eggNOG; ENOG4105C5I; Bacteria.
DR   eggNOG; COG1052; LUCA.
DR   HOGENOM; HOG000136700; -.
DR   OMA; KWIAHNG; -.
DR   OrthoDB; 1638924at2; -.
DR   BioCyc; SHAE279808:G1G27-710-MONOMER; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    318       Putative 2-hydroxyacid dehydrogenase
FT                                SH0752.
FT                                /FTId=PRO_0000312191.
FT   NP_BIND     155    156       NAD. {ECO:0000250}.
FT   NP_BIND     234    236       NAD. {ECO:0000250}.
FT   NP_BIND     283    286       NAD. {ECO:0000250}.
FT   ACT_SITE    236    236       {ECO:0000250}.
FT   ACT_SITE    265    265       {ECO:0000250}.
FT   ACT_SITE    283    283       Proton donor. {ECO:0000250}.
FT   BINDING     260    260       NAD. {ECO:0000250}.
SQ   SEQUENCE   318 AA;  34858 MW;  64713A9D033A395F CRC64;
     MEKVYIAGAI PEVGLNLLKE HFEVEMYEGE GIIDKATLME GVKDASALIS ILSTNVDQEV
     IDSASNLKII ANYGAGFNNV DVKYAREKDI DVTNTPKAST ASTAELTFGL VLAVARRIVE
     GDKLSRTQGF DGWAPLFFRG REVSGKTIGI IGLGEIGSAV AKRAKAFDMD ILYTGPHQKK
     EKEREIGAKY VDLNTLLENA DFITINAAYN PDLHHMIDTE QFKLMKSTAY LINAGRGPIV
     NEEALVKALE DKQIEGAALD VYEFEPEITE GLKSLDNVVI TPHIGNATYE ARDMMSKIVA
     NDTIKKLNGE TPQFIVNK
//
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