ID Q4N4G4_THEPA Unreviewed; 624 AA.
AC Q4N4G4;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE RecName: Full=Poly(A)-specific ribonuclease PARN {ECO:0000256|ARBA:ARBA00015918};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
DE AltName: Full=Polyadenylate-specific ribonuclease {ECO:0000256|ARBA:ARBA00031923};
GN OrderedLocusNames=TP02_0676 {ECO:0000313|EMBL:EAN32959.1};
OS Theileria parva (East coast fever infection agent).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=5875 {ECO:0000313|EMBL:EAN32959.1, ECO:0000313|Proteomes:UP000001949};
RN [1] {ECO:0000313|EMBL:EAN32959.1, ECO:0000313|Proteomes:UP000001949}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Muguga {ECO:0000313|EMBL:EAN32959.1,
RC ECO:0000313|Proteomes:UP000001949};
RX PubMed=15994558; DOI=10.1126/science.1110439;
RA Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M., Hall N.,
RA Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M., Sato S.,
RA Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J., Jiang L.,
RA Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D., Crabtree J.,
RA Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C., Suh B.,
RA Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M., Allen J.,
RA Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R., Fitzhugh H.A.,
RA Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT lymphocytes.";
RL Science 309:134-137(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001663};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN32959.1}.
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DR EMBL; AAGK01000002; EAN32959.1; -; Genomic_DNA.
DR RefSeq; XP_765242.1; XM_760149.1.
DR AlphaFoldDB; Q4N4G4; -.
DR STRING; 5875.Q4N4G4; -.
DR EnsemblProtists; EAN32959; EAN32959; TP02_0676.
DR GeneID; 3502103; -.
DR KEGG; tpv:TP02_0676; -.
DR VEuPathDB; PiroplasmaDB:TpMuguga_02g00676; -.
DR eggNOG; KOG1990; Eukaryota.
DR InParanoid; Q4N4G4; -.
DR OMA; LMHTIIG; -.
DR Proteomes; UP000001949; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR CDD; cd02325; R3H; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF22; POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1; 1.
DR Pfam; PF04857; CAF1; 1.
DR Pfam; PF08675; RNA_bind; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51061; R3H; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001949}.
FT DOMAIN 262..330
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT COILED 324..351
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 624 AA; 72581 MW; F0D180871359FCCA CRC64;
MLTKPLFSTG FYSILHKPNR NVYKKLFSTL IFTNKLSQNK ASEHHSGSLH IHLNYQNGRN
SSDFNYNLIK CGDSTLNYKN HFSTRSNVTT KPLWDLHSVI ITELIERSDF VALDVEYTGL
HVKDERFIGV DKCYESHSLG AKKFIPCQIG LTMAKYENNI WNLTTTSLFT IPSEGKSFSV
NMSTLNFLKD NNFDFNSWIR NGITHLTPKE EEERKSLIVS KLHQIRLNLQ NLSNSNIENN
GRNTNNMNTE YDVSSIKDLE DRRVVEQMIE RINKWIVDEG DEGRKPLEFE VESAFLRLLM
HSVISIKYPN LYSNSSQRNG VRCVVVYKTQ MELLEEERKV LEEELEAINK QIGLRTLFDT
VSKNNKILVG HNCFYDILHI YQTFYGDLPE NVEDFKKKWV QVFPTIFDTK YISEYYHQFT
PHTTLKSLYN SFLPNQNGFN RVKISSLGKS GMVSGYGDVI NEGEKEHEAG YDSLMTAIVF
IRQLETVIKS KNSSLNNLIN AYLDTSNTPN GMGKVIRNIF GEIMNSVRLV KCQPSVINMN
NEEDMSKHFY MFGFPNVWKK WEIMKIWSPL WVSISWIDET SCWIIAKNSE DVKNINLIYK
MMKNPQFKLY NYGQYLEKMN QSTV
//