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Database: UniProt
Entry: Q4N4G4_THEPA
LinkDB: Q4N4G4_THEPA
Original site: Q4N4G4_THEPA 
ID   Q4N4G4_THEPA            Unreviewed;       624 AA.
AC   Q4N4G4;
DT   02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   02-AUG-2005, sequence version 1.
DT   24-JAN-2024, entry version 86.
DE   RecName: Full=Poly(A)-specific ribonuclease PARN {ECO:0000256|ARBA:ARBA00015918};
DE            EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
DE   AltName: Full=Polyadenylate-specific ribonuclease {ECO:0000256|ARBA:ARBA00031923};
GN   OrderedLocusNames=TP02_0676 {ECO:0000313|EMBL:EAN32959.1};
OS   Theileria parva (East coast fever infection agent).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5875 {ECO:0000313|EMBL:EAN32959.1, ECO:0000313|Proteomes:UP000001949};
RN   [1] {ECO:0000313|EMBL:EAN32959.1, ECO:0000313|Proteomes:UP000001949}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Muguga {ECO:0000313|EMBL:EAN32959.1,
RC   ECO:0000313|Proteomes:UP000001949};
RX   PubMed=15994558; DOI=10.1126/science.1110439;
RA   Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M., Hall N.,
RA   Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M., Sato S.,
RA   Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J., Jiang L.,
RA   Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D., Crabtree J.,
RA   Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C., Suh B.,
RA   Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M., Allen J.,
RA   Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R., Fitzhugh H.A.,
RA   Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT   "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT   lymphocytes.";
RL   Science 309:134-137(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001663};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CAF1 family.
CC       {ECO:0000256|ARBA:ARBA00008372}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAN32959.1}.
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DR   EMBL; AAGK01000002; EAN32959.1; -; Genomic_DNA.
DR   RefSeq; XP_765242.1; XM_760149.1.
DR   AlphaFoldDB; Q4N4G4; -.
DR   STRING; 5875.Q4N4G4; -.
DR   EnsemblProtists; EAN32959; EAN32959; TP02_0676.
DR   GeneID; 3502103; -.
DR   KEGG; tpv:TP02_0676; -.
DR   VEuPathDB; PiroplasmaDB:TpMuguga_02g00676; -.
DR   eggNOG; KOG1990; Eukaryota.
DR   InParanoid; Q4N4G4; -.
DR   OMA; LMHTIIG; -.
DR   Proteomes; UP000001949; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR   CDD; cd02325; R3H; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR   InterPro; IPR001374; R3H_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR006941; RNase_CAF1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR   PANTHER; PTHR15092:SF22; POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1; 1.
DR   Pfam; PF04857; CAF1; 1.
DR   Pfam; PF08675; RNA_bind; 1.
DR   SUPFAM; SSF82708; R3H domain; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS51061; R3H; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001949}.
FT   DOMAIN          262..330
FT                   /note="R3H"
FT                   /evidence="ECO:0000259|PROSITE:PS51061"
FT   COILED          324..351
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   624 AA;  72581 MW;  F0D180871359FCCA CRC64;
     MLTKPLFSTG FYSILHKPNR NVYKKLFSTL IFTNKLSQNK ASEHHSGSLH IHLNYQNGRN
     SSDFNYNLIK CGDSTLNYKN HFSTRSNVTT KPLWDLHSVI ITELIERSDF VALDVEYTGL
     HVKDERFIGV DKCYESHSLG AKKFIPCQIG LTMAKYENNI WNLTTTSLFT IPSEGKSFSV
     NMSTLNFLKD NNFDFNSWIR NGITHLTPKE EEERKSLIVS KLHQIRLNLQ NLSNSNIENN
     GRNTNNMNTE YDVSSIKDLE DRRVVEQMIE RINKWIVDEG DEGRKPLEFE VESAFLRLLM
     HSVISIKYPN LYSNSSQRNG VRCVVVYKTQ MELLEEERKV LEEELEAINK QIGLRTLFDT
     VSKNNKILVG HNCFYDILHI YQTFYGDLPE NVEDFKKKWV QVFPTIFDTK YISEYYHQFT
     PHTTLKSLYN SFLPNQNGFN RVKISSLGKS GMVSGYGDVI NEGEKEHEAG YDSLMTAIVF
     IRQLETVIKS KNSSLNNLIN AYLDTSNTPN GMGKVIRNIF GEIMNSVRLV KCQPSVINMN
     NEEDMSKHFY MFGFPNVWKK WEIMKIWSPL WVSISWIDET SCWIIAKNSE DVKNINLIYK
     MMKNPQFKLY NYGQYLEKMN QSTV
//
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