ID Q4N5G1_THEPA Unreviewed; 718 AA.
AC Q4N5G1;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=mRNA (guanine-N(7))-methyltransferase {ECO:0000256|ARBA:ARBA00011926};
DE EC=2.1.1.56 {ECO:0000256|ARBA:ARBA00011926};
GN OrderedLocusNames=TP02_0329 {ECO:0000313|EMBL:EAN32612.1};
OS Theileria parva (East coast fever infection agent).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=5875 {ECO:0000313|EMBL:EAN32612.1, ECO:0000313|Proteomes:UP000001949};
RN [1] {ECO:0000313|EMBL:EAN32612.1, ECO:0000313|Proteomes:UP000001949}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Muguga {ECO:0000313|EMBL:EAN32612.1,
RC ECO:0000313|Proteomes:UP000001949};
RX PubMed=15994558; DOI=10.1126/science.1110439;
RA Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M., Hall N.,
RA Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M., Sato S.,
RA Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J., Jiang L.,
RA Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D., Crabtree J.,
RA Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C., Suh B.,
RA Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M., Allen J.,
RA Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R., Fitzhugh H.A.,
RA Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT lymphocytes.";
RL Science 309:134-137(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA +
CC S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-
CC triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA-
CC COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461,
CC ChEBI:CHEBI:167617; EC=2.1.1.56;
CC Evidence={ECO:0000256|ARBA:ARBA00024288};
CC -!- SIMILARITY: In the N-terminal section; belongs to the dsDNA virus mRNA
CC guanylyltransferase family. {ECO:0000256|ARBA:ARBA00008556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN32612.1}.
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DR EMBL; AAGK01000002; EAN32612.1; -; Genomic_DNA.
DR RefSeq; XP_764895.1; XM_759802.1.
DR AlphaFoldDB; Q4N5G1; -.
DR STRING; 5875.Q4N5G1; -.
DR EnsemblProtists; EAN32612; EAN32612; TP02_0329.
DR GeneID; 3502313; -.
DR KEGG; tpv:TP02_0329; -.
DR VEuPathDB; PiroplasmaDB:TpMuguga_02g00329; -.
DR eggNOG; KOG1975; Eukaryota.
DR InParanoid; Q4N5G1; -.
DR OMA; FLMESID; -.
DR Proteomes; UP000001949; Unassembled WGS sequence.
DR GO; GO:0004482; F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004971; mRNA_G-N7_MeTrfase_dom.
DR InterPro; IPR039753; RG7MT1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12189:SF2; MRNA CAP GUANINE-N7 METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12189; MRNA GUANINE-7- METHYLTRANSFERASE; 1.
DR Pfam; PF03291; mRNA_G-N7_MeTrfase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51562; RNA_CAP0_MT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000001949};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 367..708
FT /note="MRNA cap 0 methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51562"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 83618 MW; 9EDF88BF89EDABC9 CRC64;
MINRPKSRRK VSKEDSTDSG FKELTSSDNP LLIEGYNLFD KQYNENTIHN RICHSIKESL
DSISDPLSCN VVFQIGKLMS VVKSRSIYLP TETEAVLDFD FNKVKFVPNI SKQCLDSLYL
NLFVSKSDYC KLVQNNDYLE VELVYNTKTG NSDSKVNNKE GFCHSIIYRI PFIFNEKLNF
NDLKQYTYNY LDSIIVYRPQ SDYHFKVQTN CIISVNHNAT ETRGSVLKML FRHLRTYNTN
KLENVKFIKF NLEVVDEWDI PINDELCGLG IQELITSFYE TFIATNSSNS NPFIDVDNSE
ESKVKIIQVS TDSSKIPNNS QLYRQYKRLI ESKPNRFGYI VSLLESNTRM LLDLFNGTLV
DSQLDTLDRK DDALDYYPNL FGDTAEFAQI HYDTRKVIRQ QESAIEALRK YNNLVKRVLI
LCNIKKNASV LELACGHAQD LDKYNTKKIR KLMGIDISLR EINEARRRYG QRKRTLSFNA
EFHHGNLLDP KIYSMFIKNN TFDVVSIQLA IHYMLDTETS TNFILEKIHN SLNEGGLFIG
STICCDQLSK ELASNLNNSH SSEVWEFGNP IFKITMDEKS VEEIKNSSES LSYTEINEVL
NSNWGLKYHF FLMESIDESE YVVPWRKFVN LCSKIGLKLV ESHPFQEYLE LYKALFDSKK
LDLPQDVYEN MDYHFKNISN YVFSNDQMRV FSLYKIFIFQ KITGRDKLYI QGVKIKKS
//