ID Q4N8V8_THEPA Unreviewed; 568 AA.
AC Q4N8V8;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Actin {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=TP01_0356 {ECO:0000313|EMBL:EAN33600.1};
OS Theileria parva (East coast fever infection agent).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=5875 {ECO:0000313|EMBL:EAN33600.1, ECO:0000313|Proteomes:UP000001949};
RN [1] {ECO:0000313|EMBL:EAN33600.1, ECO:0000313|Proteomes:UP000001949}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Muguga {ECO:0000313|EMBL:EAN33600.1,
RC ECO:0000313|Proteomes:UP000001949};
RX PubMed=15994558; DOI=10.1126/science.1110439;
RA Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M., Hall N.,
RA Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M., Sato S.,
RA Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J., Jiang L.,
RA Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D., Crabtree J.,
RA Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C., Suh B.,
RA Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M., Allen J.,
RA Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R., Fitzhugh H.A.,
RA Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT lymphocytes.";
RL Science 309:134-137(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001836};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the actin family.
CC {ECO:0000256|ARBA:ARBA00006752, ECO:0000256|RuleBase:RU000487}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN33600.1}.
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DR EMBL; AAGK01000001; EAN33600.1; -; Genomic_DNA.
DR RefSeq; XP_765883.1; XM_760790.1.
DR AlphaFoldDB; Q4N8V8; -.
DR STRING; 5875.Q4N8V8; -.
DR EnsemblProtists; EAN33600; EAN33600; TP01_0356.
DR GeneID; 3502892; -.
DR KEGG; tpv:TP01_0356; -.
DR VEuPathDB; PiroplasmaDB:TpMuguga_01g00356; -.
DR eggNOG; KOG0676; Eukaryota.
DR eggNOG; KOG0680; Eukaryota.
DR InParanoid; Q4N8V8; -.
DR OMA; DICAPPR; -.
DR Proteomes; UP000001949; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 3.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; ACTIN; 1.
DR PANTHER; PTHR11937:SF387; ACTIN; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000001949}.
FT REGION 52..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 63933 MW; 313E3F3539E1DBB3 CRC64;
MDSSAYATLP RVVLENGSGY VKIGMAGNRK PPHVIPNCIG QPKKKASSYY IETHSSANSD
EKDRSQSHSV SESSGFVSDS CYTLIEYFCN RPQINSLVYD PDRQRMVWDK YIGRSHLTKK
DGLISPGNYL SVIPESTSIC LTEANLCPAQ SRQLSAEIIF EDFGFPLACF LSSQTASAYF
YQNFTPSRAK SDPVLYSYPD SVTLTSRSSP NNSQTSKQEH DQRNNFKDMN LSCCLVVDCG
FGSTHAVPFV NGVPIQNAAL RTNSGGSQCN SYLKNITAIR SVNLEFNELV VQHMKEESCY
VSLDFDLELK AAKRLIKLYG THLLSHQYIL PIYTSKSKTL MSKHFTNYRK TKPPLLNENN
EDLIKALVSG EITDIKQLEP TSTISENNTG SNTPNDTNNE DGNDDAREGL KELNELNGEE
YERDEDETQY VELFAERFSV PEIIFNPQDI KLNDCGIVEL AYRSISLCPP AIQPLLTNNI
FICGGTTKFR GFIKRFYKDL RPMIPQEWDI RLYSTDDPML ASFYGARMWT NNDAVFLSSA
ITRSEYFENG ASVIKIKEQP KSKTDYVL
//
