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Database: UniProt
Entry: Q4P5U4
LinkDB: Q4P5U4
Original site: Q4P5U4 
ID   DBP4_USTMA              Reviewed;         916 AA.
AC   Q4P5U4; A0A0D1DY19;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 2.
DT   11-DEC-2019, entry version 93.
DE   RecName: Full=ATP-dependent RNA helicase DBP4;
DE            EC=3.6.4.13;
GN   Name=DBP4; ORFNames=UMAG_11989;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-dependent RNA helicase required for ribosome biogenesis.
CC       Involved in the release of U14 snoRNA in pre-ribosomal complexes.
CC       Required for pre-rRNA cleavage at site A2 (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Interacts with the U3 and U14 snoRNAs. Associates with pre-
CC       ribosomal complexes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC       family of RNA helicases and controls ATP binding and hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX10/DBP4
CC       subfamily. {ECO:0000305}.
DR   EMBL; CM003152; KIS67420.1; -; Genomic_DNA.
DR   RefSeq; XP_011391015.1; XM_011392713.1.
DR   SMR; Q4P5U4; -.
DR   STRING; 5270.UM04519P0; -.
DR   EnsemblFungi; KIS67420; KIS67420; UMAG_11989.
DR   GeneID; 23567787; -.
DR   KEGG; uma:UMAG_11989; -.
DR   EuPathDB; FungiDB:UMAG_11989; -.
DR   InParanoid; Q4P5U4; -.
DR   KO; K14776; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000000561; Chromosome 13.
DR   Proteomes; UP000000561; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0034512; F:box C/D snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008186; F:RNA-dependent ATPase activity; IEA:EnsemblFungi.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR025313; DUF4217.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF13959; DUF4217; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01178; DUF4217; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW   Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..916
FT                   /note="ATP-dependent RNA helicase DBP4"
FT                   /id="PRO_0000256004"
FT   DOMAIN          89..263
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          277..442
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   NP_BIND         102..109
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   MOTIF           58..86
FT                   /note="Q motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00552"
FT   MOTIF           211..214
FT                   /note="DEAD box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   COMPBIAS        807..870
FT                   /note="Asp-rich"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00004"
SQ   SEQUENCE   916 AA;  101773 MW;  DEB1667F04C863F0 CRC64;
     MPPSSAAEGS TKRKKGGAAP HLKSRSKNAR KLKRSAEDAE IAQLEQGIQA FVSPIDLKQF
     TQLPLSDRTC RGLKRAGYTD MTDIQAKSLS LSLKGKDVLG AARTGSGKTL AFLIPVLEIL
     YRRKWGPSDG LGALVISPTR ELAIQIFEVL RKIGSYHTFS AGLVIGGKDV KQEKDRLSRI
     NILIATPGRL LQHMDQTLGF DTSNVQVLVL DEADRILDMG FSRTLNAIVE NLPRNRQTML
     FSATQTKRVK DLARLSLQDP EYVAVREPEN EGCTPRGLEQ HYMLVELEKK LDLLFSFIRT
     HTKCKALVFM SSCRQVQFVH ETFCKLRPGV SLMALHGKQK QAKRLQIFTQ FTKTQHALLF
     ATDIAARGLD FPAVDWVIQL DVPEDVDTYI HRVGRTARYT AKGNSLLFVL PSEEKGILEA
     LATKNIAIGR IKPKESKTQS IQNQLQAFAF QEPQIKHLAQ KAFVSYVRSI HLQKNKEIFD
     VTALALEPFA AALGLPGAPK VKFVKEAAKA KKAAAYKAAQ QQADDNSGQV KGDSDDEQAE
     RADKNGKVRT KYDRMFERKN QDILSKHYAN LIADDASSEQ DSSNDSDTSD DDSVSVATTD
     NDDAEDREET RYGRSAGRRK ENRLVGSDTS DSEEDESDDE QNDSGLHKIK SETKRSVMAA
     RGDGDDGFLT LKRADHALED DGDAYGIGGD DTRITMEQAK ADATENLSKR KLAMGQSKKA
     LALAGKRGIG EKLIFDEHGE AHALYELQDE EAFNKQGDAK TQAQRWAEEE RERMQQADAK
     DKELAKEKRR EKRRRQKERE KALERGDAPD NGDEGGSGDD DEEEEETGGR AVLAPIDNRS
     DGYETPDFDL TTEEDEDDDD DADDDDDDDD EAYRAPAPKR RKMAPSAGVT SQPSHSKKSK
     LEQEEELALR LLAGDA
//
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