ID CLF1_USTMA Reviewed; 781 AA.
AC Q4PB37; A0A0D1E0D3;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Pre-mRNA-splicing factor CLF1;
GN Name=CLF1; ORFNames=UMAG_02676;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC Required for the spliceosome assembly and initiation of the DNA
CC replication (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR EMBL; CM003145; KIS69336.1; -; Genomic_DNA.
DR RefSeq; XP_011389057.1; XM_011390755.1.
DR AlphaFoldDB; Q4PB37; -.
DR SMR; Q4PB37; -.
DR STRING; 237631.Q4PB37; -.
DR EnsemblFungi; KIS69336; KIS69336; UMAG_02676.
DR GeneID; 23563367; -.
DR KEGG; uma:UMAG_02676; -.
DR VEuPathDB; FungiDB:UMAG_02676; -.
DR eggNOG; KOG1915; Eukaryota.
DR HOGENOM; CLU_011554_1_0_1; -.
DR InParanoid; Q4PB37; -.
DR OMA; HIKVWIS; -.
DR OrthoDB; 5479069at2759; -.
DR Proteomes; UP000000561; Chromosome 6.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246:SF3; CROOKED NECK-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR Pfam; PF02184; HAT; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00386; HAT; 13.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..781
FT /note="Pre-mRNA-splicing factor CLF1"
FT /id="PRO_0000205751"
FT REPEAT 50..82
FT /note="HAT 1"
FT REPEAT 84..116
FT /note="HAT 2"
FT REPEAT 118..150
FT /note="HAT 3"
FT REPEAT 152..183
FT /note="HAT 4"
FT REPEAT 185..216
FT /note="HAT 5"
FT REPEAT 218..257
FT /note="HAT 6"
FT REPEAT 259..293
FT /note="HAT 7"
FT REPEAT 308..340
FT /note="HAT 8"
FT REPEAT 357..391
FT /note="HAT 9"
FT REPEAT 401..437
FT /note="HAT 10"
FT REPEAT 439..470
FT /note="HAT 11"
FT REPEAT 472..504
FT /note="HAT 12"
FT REPEAT 506..547
FT /note="HAT 13"
FT REPEAT 549..580
FT /note="HAT 14"
FT REPEAT 628..665
FT /note="HAT 15"
FT REGION 586..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..781
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 91290 MW; 5741179FA14BA4A0 CRC64;
MSRSAPRIKN RAPAPIQISA EQLLREAQER QEAPASAPVQ KIEDYEELEE YRGRRRSEFE
DRLRRNGLNM STWIKYASWE ASQGEMDRCR SIYERALDVE PHHLPLWLRY TEQELKMRNV
QHARNLYDRA VSILPRIDQL WYKYVHLEEL LGNIPGTRQV FERWMKWEPE EKAWHAYINL
EVRYDELDRA SAIWERCVTC HPVPKQWIRW AKFEEDRGNL EKARIVFQMA LDYIGEDEDA
MEKAQSVFTA FAKMETRLKE YERARVIYKY ALERLPRSKS EGIYSSYTRF EKQFGTMNSV
EDTVIGKRRI QYEEELAAQE AGGAPADYDT WFDYSRLEED AYRALLATGG SQDQLQQAVK
RVREVYERAI AQVPSSQEKR DWRRYIFLWL RYALFEEIDT RDYDRTREIY KAAIALVPHR
RFTFAKLWVQ YARFEVRRLE LTAARKILGA AIGMAPKLKL FSSYIELEVS LKEFDRARKI
YEKALEWDPT NSQTWVRFAE LEKNLFDTDR ARALFELGVG QAEGGEASGG LDMPEIVWKA
YIDFEFEERE WEKVDALYER LLAKSGHVKV WISYALSKIN RATAIEEDED EEDDDHDHDD
DMAATPSREL TEEEEALRQQ RRSALASSAR EIFQRAYDNL KSRSLKDERV ALLESWKSFE
QQHGSAETLS RVEAKFPRVV KKRRQVEDSA DGAMEEYYDL IFPDDQDEGK GAFKLLQMAH
AWRAAQAAKE QQQQQQQSSS AETGASASAG AGATGDDVRD EESIGIAIDD DQEQDASGEE
A
//
