GenomeNet

Database: UniProt
Entry: Q4PBL3
LinkDB: Q4PBL3
Original site: Q4PBL3 
ID   SET2_USTMA              Reviewed;         972 AA.
AC   Q4PBL3; A0A0D1CU33;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   13-FEB-2019, entry version 93.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 specific;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain-containing protein 2;
GN   Name=SET2; ORFNames=UMAG_02500;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T.,
RA   Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O.,
RA   Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J.,
RA   Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.,
RA   Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W.,
RA   Guzman P., Farman M.L., Stajich J.E., Sentandreu R.,
RA   Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J.,
RA   Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M.,
RA   Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S.,
RA   Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U.,
RA   Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W.,
RA   Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K.,
RA   Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen
RT   Ustilago maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G.,
RA   Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histone methyltransferase that methylates histone H3 to
CC       form H3K36me. Involved in transcription elongation as well as in
CC       transcription repression (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00901};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- DOMAIN: The AWS and SET domains are necessary for transcription
CC       repression. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SET2 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00901}.
DR   EMBL; CM003144; KIS69988.1; -; Genomic_DNA.
DR   RefSeq; XP_011388777.1; XM_011390475.1.
DR   ProteinModelPortal; Q4PBL3; -.
DR   SMR; Q4PBL3; -.
DR   STRING; 5270.UM02500P0; -.
DR   PRIDE; Q4PBL3; -.
DR   EnsemblFungi; KIS69988; KIS69988; UMAG_02500.
DR   GeneID; 23563234; -.
DR   KEGG; uma:UMAG_02500; -.
DR   EuPathDB; FungiDB:UMAG_02500; -.
DR   InParanoid; Q4PBL3; -.
DR   KO; K11423; -.
DR   OMA; RHAKELT; -.
DR   OrthoDB; 453286at2759; -.
DR   Proteomes; UP000000561; Chromosome 5.
DR   Proteomes; UP000000561; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IBA:GO_Central.
DR   GO; GO:0006354; P:DNA-templated transcription, elongation; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.1740.100; -; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR025788; Hist-Lys_N-MeTrfase_SET2_fun.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR038190; SRI_sf.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51568; SAM_MT43_SET2_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromosome; Coiled coil; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; Repressor; S-adenosyl-L-methionine;
KW   Transcription; Transcription regulation; Transferase.
FT   CHAIN         1    972       Histone-lysine N-methyltransferase, H3
FT                                lysine-36 specific.
FT                                /FTId=PRO_0000269793.
FT   DOMAIN      191    244       AWS. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00562}.
FT   DOMAIN      246    363       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN      370    386       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   COILED      770    806       {ECO:0000255}.
FT   COMPBIAS     58    118       Pro-rich.
FT   COMPBIAS    743    765       Gln-rich.
FT   COMPBIAS    810    862       Ser-rich.
SQ   SEQUENCE   972 AA;  107431 MW;  7A128A157E625DB6 CRC64;
     MDWDHNVTFS AVRSLQATTA VAQATDNVVD LDRNRVDSRP GVLPTKNESS PHSSASLPPP
     SPHPPPPPAF TPSPSPSPSP SPQTATARSS VTDAAPAPKR SPRSPLHSNG SFPPVSDPIS
     SIDSRDALDI DHESTAMLAS SSSARKSKPK LQPQLINHLP LAQQAAMATF HEITFNDYHD
     KKLGRPPGKF DDYMICDCTP NSGNLDMACT DYSGCINRMT QIECSASKCR WGKQCRNQRF
     HRRQYVDVDI VQTEKKGFGL RACQDIPKET FIYEYVGEVM NQTTFLQRMQ QYRIEGIRHF
     YFMMLQPNEY LDATKKGGKG RFINHSCNPN CAVSKWQVGK HLRMGIFAKR NIQKGEELTF
     NYNVDRYGND AQECFCGEPN CVGTLGGKTQ TDLSGMDDLF LDALGISDEV EQTEAKGSRR
     KRGKRLDLDF IPQMRAIQEH EATRVMTAAR QAGPKREILE KLLRRMEMTT DVNVQKSLVK
     LHGFILMQFL LEQWWNDRDI VILIINVLAR WPLIARNKVI DCGVEDQVRI LAQTYRPRSP
     EDQKPSLDAL RQVKQDDSAA DRNDYTQVQP TLAPVRIGAP PAPDAEVSAR AEHLLEAWKK
     LDMTYRIARK DALKPDADDH KDATAVTTWI DRRRMQDLDD PLDLEHAQAP NAVSSELGNA
     LSGDQELREI KPSWQPPPAP PSMPNAPAKR MGGAVHHRSP PGSFTPTRLQ SSGQSPLTPD
     QVTSVLSSSL VKSLSGLVSS LKQQGIQLQQ QQQQQPPAQQ QPSAQPAAPS AKSIEDIIRE
     ANEQEERARK EAEAAAKAAR ELEVNGGQTS GSSRKRPSSA SRHSDKRAKH SSLSSSSQAA
     SKLISSNGSA ADSTSKAGSV ESVAANERRL RKLVGELVVR QMSKYKDDLE RESFKRHAKE
     LTNAIVGKEM RNPKSWPPAR GALTELSLDK RAKIKAFAKE YIDKLLARKG KGKGSSTPSN
     NEGAGSSNNG IV
//
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