GenomeNet

Database: UniProt
Entry: Q4PGG5
LinkDB: Q4PGG5
Original site: Q4PGG5 
ID   RAD5_USTMA              Reviewed;        1387 AA.
AC   Q4PGG5; A0A0D1EB15;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-OCT-2019, entry version 94.
DE   RecName: Full=DNA repair protein RAD5;
DE            EC=3.6.4.-;
GN   Name=RAD5; ORFNames=UMAG_00798;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T.,
RA   Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O.,
RA   Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J.,
RA   Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.,
RA   Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W.,
RA   Guzman P., Farman M.L., Stajich J.E., Sentandreu R.,
RA   Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J.,
RA   Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M.,
RA   Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S.,
RA   Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U.,
RA   Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W.,
RA   Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K.,
RA   Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen
RT   Ustilago maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G.,
RA   Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable helicase, member of the UBC2/RAD6 epistasis
CC       group. Functions with DNA repair protein RAD18 in error-free
CC       postreplication DNA repair. Involved in the maintenance of wild-
CC       type rates of instability of simple repetitive sequences such as
CC       poly(GT) repeats. Seems to be involved in maintaining a balance
CC       which acts in favor of error-prone non-homologous joining during
CC       DNA double-strand breaks repairs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC       {ECO:0000305}.
DR   EMBL; CM003140; KIS72396.1; -; Genomic_DNA.
DR   RefSeq; XP_011386570.1; XM_011388268.1.
DR   SMR; Q4PGG5; -.
DR   STRING; 5270.UM00798P0; -.
DR   PRIDE; Q4PGG5; -.
DR   EnsemblFungi; KIS72396; KIS72396; UMAG_00798.
DR   GeneID; 23562003; -.
DR   KEGG; uma:UMAG_00798; -.
DR   EuPathDB; FungiDB:UMAG_00798; -.
DR   InParanoid; Q4PGG5; -.
DR   KO; K15505; -.
DR   OMA; RVFMMDP; -.
DR   OrthoDB; 132523at2759; -.
DR   Proteomes; UP000000561; Chromosome 1.
DR   Proteomes; UP000000561; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   Gene3D; 3.40.50.10810; -; 2.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR014905; HIRAN.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF08797; HIRAN; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00910; HIRAN; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA repair;
KW   DNA-binding; Helicase; Hydrolase; Metal-binding; Nucleotide-binding;
KW   Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN         1   1387       DNA repair protein RAD5.
FT                                /FTId=PRO_0000056128.
FT   DOMAIN      645    880       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN     1213   1379       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     658    665       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   ZN_FING    1108   1154       RING-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00175}.
FT   MOTIF       831    834       DEAH box.
SQ   SEQUENCE   1387 AA;  152271 MW;  B0DB7AFE8DF34146 CRC64;
     MTTQSSAGPQ SQPSRDFFAS SPSATPGSPS KQASQASKQP DALVTPSSVT ANTSVCADNL
     LDHHQHEPQH DAASVVIGIE GSINDSAAIH RRRQQPRRAA VQNAKPLFLA EDEDDAINWP
     VADQEEGDDF FSTQLADQKV KRPARATVNS DEKDFQPSTL SSLSSPPSET VYKRSPPSDD
     VQASNGPAKR PKKSWSTPAS VATTKSAPRH CSPTPDPRLR HDAFDRRYIG TFVLSAWSLS
     KGSSYVKPGD AVRIFRPRKK HATAEPKIAS KLTNGGMQKA KQTTLNFRGA SAGPTNFFTS
     KQKSKEKEHF IVRFSNMRGF EVGRLPLEVA IWMSKLIDAG IAEFEGVVVD CPPSLTVGCD
     IILQVKAYIK FDAFFSTLLG SREFDDQNEA LRPETAESDL EKTLRERKIS LLRMFRVCDL
     KPRLSNAILK SHKASDDFSS EAMLDQYGGD IQGAVKHAGS DLAISTENGT QLPHAGEDAS
     STAIDLDVEG DTDAVAHLEI ADQLQSAKRQ TDGDADTEEN DGTELNLNQL DQVYRKAQAN
     DAHLPEVEPP ESFVLTLRPY QKQALGWMKN MEMAPGQSSS SQEQSVTQQG NGDTGERNVS
     LHPLWEEYEF PLDYDNPQAN ERLILSATRL FYFNPYTGDL SLDFQRASKG SRGGILADEM
     GLGKTIMVAS LLHANRTSDP GEESEGEINA VDAAEGDVST KRKGSAKQTS LASAFAASTS
     SVDQRKALLK ASVSKGKASL VVAPMSLIGQ WRDELIRASA PGSLTPVLYY ADTKGDLLAQ
     LESGKVDVVI TSYGTLVTEY RRFLDGGGAS NRHLSVSAPL YCIDWLRVIL DEAHNIKNRS
     TMNARACCDL VSRRRWALTG TPIINRLTDL FSLLKFLRVE PWGDFSFFNS FVCKPFQAKS
     TKALDVVQVI LESVLLRREK KMKDKDGKPI VELPPKTIVV KELEFSELER RIYDNVYRRA
     YLQFASLKAN GTVTRNLSVI FSVLMRLRQA VCHPSLVLKA GSKVQSGGIR KDHVDRNGEV
     GVGEGDHVEV DADAVEFGLD SDHVGGNGTP STQDLRELVA QFQLDEAGEA GDDSTESYTK
     ATVERLIGEM HGDQATVPPV VSDGENECPI CLEESQISPC YLPRCMHSAC KACLVDYLGQ
     CKQKGDQGAC PTCRKGPVQE TDLIEAIRTR PATRAASGGA SPTDRPGKAC TLTSVPSVIY
     VRNNLRTSTK LSALISHLNT LRATEAAFKG VIFSQFTSFL DLIEPVLTRY RFHFLRLDGS
     TPQKVRDKLV LEFQSPSPTN HVVLFLISLK AGGVGLNLTA ANKIWLLDFW WNSSIENQAI
     DRIHRFGQTS PVSVFRYIIK DSIEDRILLI QKRKDMLIKH ALNTDNHPHG TKPNSEMLAN
     LDLLFGE
//
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