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Database: UniProt
Entry: Q4Q1F5_LEIMA
LinkDB: Q4Q1F5_LEIMA
Original site: Q4Q1F5_LEIMA 
ID   Q4Q1F5_LEIMA            Unreviewed;       463 AA.
AC   Q4Q1F5;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   08-MAY-2019, entry version 86.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   ORFNames=LMJF_36_2660 {ECO:0000313|EMBL:CAJ09224.1};
OS   Leishmania major.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664 {ECO:0000313|Proteomes:UP000000542};
RN   [1] {ECO:0000313|EMBL:CAJ09224.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M.,
RA   Cadag E., Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K.,
RA   Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A.,
RA   Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C.,
RA   Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D.,
RA   Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L.,
RA   Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S.,
RA   Mottram J.C., Muller-Auer S., Munden H., Nelson S., Norbertczak H.,
RA   Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B.,
RA   Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J.,
RA   Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D.,
RA   Schafer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S.,
RA   Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C.,
RA   Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S.,
RA   Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.,
RA   Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
RN   [2] {ECO:0000313|EMBL:CAJ09224.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural
RT   change between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; FR796432; CAJ09224.1; -; Genomic_DNA.
DR   RefSeq; XP_001686843.1; XM_001686791.1.
DR   STRING; 5664.LmjF.36.2660; -.
DR   EnsemblProtists; CAJ09224; CAJ09224; LMJF_36_2660.
DR   GeneDB; LmjF.36.2660:pep; -.
DR   GeneID; 5655554; -.
DR   KEGG; lma:LMJF_36_2660; -.
DR   EuPathDB; TriTrypDB:LmjF.36.2660; -.
DR   eggNOG; KOG0557; Eukaryota.
DR   eggNOG; COG0508; LUCA.
DR   HOGENOM; HOG000281566; -.
DR   InParanoid; Q4Q1F5; -.
DR   KO; K00627; -.
DR   Proteomes; UP000000542; Chromosome 36.
DR   GO; GO:0020023; C:kinetoplast; ISO:GeneDB.
DR   GO; GO:0005739; C:mitochondrion; ISO:GeneDB.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:CAJ09224.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000542};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:CAJ09224.1}.
FT   DOMAIN      149    187       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
SQ   SEQUENCE   463 AA;  48751 MW;  7B6907D780C0E888 CRC64;
     MLRCRAVSKL ATLAALRFLT ITPIPMPALS PTMEKGKITE WCKQPGDFIR PGDTFCNIET
     DKAVVSYDNA TEEGFFARVI TSPGEETVVG QTVCLIVDEK EGVHSDEVKN WKPEAEEAPA
     AAAEEAPAAP AATTPVAAAP VAASGDRVKA SPYARKMAAE KNVSLRGIKG TGGGVGRITS
     KDVAAAVASG TASSAAEVAA PAKTAATAAL AAPAKPAAAK GTPPANPNFT DIPVTTMRSV
     IAKRLHQSKN LEIPHYYLFD DCRVDNMLAL IKQLNAKGNG EYKITVNDYI VKAVARANTL
     VPEVNSSWQG DFIRQYATVD VSVAVATPTG LITPIIRNAQ AKGLVEISKE TKALAKKARD
     GTLQPSEFQG GTCSVSNLGA TGIPGFTAII NPPQAMILAV GSAKPRAEIV KSEETGEFEM
     TGRVENVVSF SASFDHRIVD GALGAKWFQH FHDAMENPLS LLL
//
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