ID Q4Q1G2_LEIMA Unreviewed; 571 AA.
AC Q4Q1G2;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE SubName: Full=Putative membrane-bound acid phosphatase 2 {ECO:0000313|EMBL:CAJ09217.1};
GN ORFNames=LMJF_36_2590 {ECO:0000313|EMBL:CAJ09217.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ09217.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ09217.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ09217.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; FR796432; CAJ09217.1; -; Genomic_DNA.
DR RefSeq; XP_001686836.1; XM_001686784.1.
DR AlphaFoldDB; Q4Q1G2; -.
DR EnsemblProtists; CAJ09217; CAJ09217; LMJF_36_2590.
DR GeneID; 5655536; -.
DR KEGG; lma:LMJF_36_2590; -.
DR VEuPathDB; TriTrypDB:LmjF.36.2590; -.
DR VEuPathDB; TriTrypDB:LMJFC_360037900; -.
DR VEuPathDB; TriTrypDB:LMJLV39_360034200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_360034200; -.
DR eggNOG; KOG3720; Eukaryota.
DR HOGENOM; CLU_039467_0_0_1; -.
DR InParanoid; Q4Q1G2; -.
DR OMA; LMHYSAH; -.
DR Proteomes; UP000000542; Chromosome 36.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF110; ACID PHOSPHATASE 1, ISOFORM B; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..571
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004241217"
FT TRANSMEM 504..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 546..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 62622 MW; 6A65989A801C648B CRC64;
MACFARLGWA AVLAAVLIAC AISIAHAQST IARDGAADAK DIMKVLQVNV LHRHGARSGL
PRENTTEICT ESPCGYLSWA GIEMLLKVGS FLRTRYNTDP SVVSSPMFES PNYDLDVAYS
RSTDVLRTLQ SAEAFLRGFF PNMSSLYAAI HTMPESTDVL LNSNTQPWLK FFYSNNKALL
RAVCNPLTDE LFPNWKDITK IGAEIYQEGY CSDYETRSDC VRTLFDIAAA KKAIGELNQY
PLLEANFEKL KRVTTALFDY EYHYNHSDPL MFRQGGRGQP FVQQLVTNME GVIEGSNKYK
LMHYSAHDTS LGPVWGTLGD RTPDGMMPPF AQVLVAELLQ NSPTGAHYVR ILRGNPGQSP
DTKFEFEWDS KWEMQCIDAL GTAYKAEGNI CPFADFKRFV KWSEPADARG YCYLDQVSID
IAGCPSEPVA YGTPPTALVS STCQFYRSAC PQFACGIGET LNSVSMQCVC SKDSCLGGKT
NEESSGDAAV DTDKKPTLRE SNGLSAGAVA GVSLATFCAG AIIAVAATAA ICVCKRRSQY
QQHVRMSSTV EEGNQLNDER EGAAKDFKEG I
//
