ID Q4Q2Z9_LEIMA Unreviewed; 629 AA.
AC Q4Q2Z9;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Regulator of chromosome condensation {ECO:0008006|Google:ProtNLM};
GN ORFNames=LMJF_34_2020 {ECO:0000313|EMBL:CAJ07914.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ07914.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ07914.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ07914.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796430; CAJ07914.1; -; Genomic_DNA.
DR RefSeq; XP_001686299.1; XM_001686247.1.
DR AlphaFoldDB; Q4Q2Z9; -.
DR STRING; 5664.Q4Q2Z9; -.
DR EnsemblProtists; CAJ07914; CAJ07914; LMJF_34_2020.
DR GeneID; 5654968; -.
DR KEGG; lma:LMJF_34_2020; -.
DR VEuPathDB; TriTrypDB:LmjF.34.2020; -.
DR VEuPathDB; TriTrypDB:LMJFC_340028100; -.
DR VEuPathDB; TriTrypDB:LMJLV39_340024700; -.
DR VEuPathDB; TriTrypDB:LMJSD75_340025200; -.
DR eggNOG; KOG1426; Eukaryota.
DR HOGENOM; CLU_435115_0_0_1; -.
DR InParanoid; Q4Q2Z9; -.
DR OMA; TSCFIDR; -.
DR Proteomes; UP000000542; Chromosome 34.
DR GO; GO:0005938; C:cell cortex; ISO:GeneDB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1.
DR PANTHER; PTHR22870:SF437; X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR-RELATED; 1.
DR Pfam; PF13540; RCC1_2; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 324..376
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 377..429
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REGION 479..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 68498 MW; 95C79A46703716D8 CRC64;
MITDAEFWQE IRRSMSGGEC IFSSMLALIH ARQSAIDAHV TTPEREVHKL TTWGQKRHDE
VTGRVFTSEQ KREMEMEARE KEARLKEIDK PLEANKAFRA GRVPEDTPVY GVSSSTMCVL
QQVMMFAVPI YVLRYNVPAM SMSWNTSCFI DRQSKQLITF GSGHGVKVPQ HLRGRGCVAG
DGFFAILTNQ DEVWSSGGLK VSSSSIDGPT ALGREDAMTG IAGKTLMLVG HGQRLAIVTR
AFTVRSLSAL SNPIRSIMPH RHVRFLDLGY GEDYYMVGTD SIVYKTTASR RAVSTPRRVM
TLCRTPVSRI ASGMGFLLII DQNGHLLSFG RNKKGQLGNG EVQDARRKPY FQQKLTHHYF
VQVSAGDCHS LALTSNGIVY GAGSNESGQL GLGRSLKQVC KFTPIPLGND MRCIGIAAGP
AGSMFYCDNG RVLTCGLNDS MQLGLETSEK IVFEPTPIAV IFNGVESYTL DFGGFCRPEG
ESRAPPADMP GAVGEEGGIS SSSPAMVSAL YRNKASSNRA SQETTVINFS ETSGNNTTNA
NNTNEKNANA TPTETARPGE NSGTQEDHQP VENNISANDS TVERRNEKGK PKTRHDENAH
NGGQNDAVKG RGKFKAKETK PKCGCCTVV
//
