ID Q4Q396_LEIMA Unreviewed; 1436 AA.
AC Q4Q396;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Dihydroxyacetonephosphate acyltransferase {ECO:0000313|EMBL:CAJ07816.1};
DE EC=2.3.1.42 {ECO:0000313|EMBL:CAJ07816.1};
GN Name=DAT {ECO:0000313|EMBL:CAJ07816.1};
GN ORFNames=LMJF_34_1090 {ECO:0000313|EMBL:CAJ07816.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ07816.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ07816.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ07816.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the GPAT/DAPAT family.
CC {ECO:0000256|ARBA:ARBA00007937}.
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DR EMBL; FR796430; CAJ07816.1; -; Genomic_DNA.
DR RefSeq; XP_001686202.1; XM_001686150.1.
DR STRING; 5664.Q4Q396; -.
DR EnsemblProtists; CAJ07816; CAJ07816; LMJF_34_1090.
DR GeneID; 5654871; -.
DR KEGG; lma:LMJF_34_1090; -.
DR VEuPathDB; TriTrypDB:LmjF.34.1090; -.
DR VEuPathDB; TriTrypDB:LMJFC_340019400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_340018500; -.
DR VEuPathDB; TriTrypDB:LMJSD75_340018600; -.
DR eggNOG; KOG3730; Eukaryota.
DR HOGENOM; CLU_266644_0_0_1; -.
DR InParanoid; Q4Q396; -.
DR OMA; NQLIHVC; -.
DR Proteomes; UP000000542; Chromosome 34.
DR GO; GO:0020022; C:acidocalcisome; ISO:GeneDB.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0020015; C:glycosome; IDA:GeneDB.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0004366; F:glycerol-3-phosphate O-acyltransferase activity; IBA:GO_Central.
DR GO; GO:0016287; F:glycerone-phosphate O-acyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008611; P:ether lipid biosynthetic process; IDA:GeneDB.
DR GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IBA:GO_Central.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IBA:GO_Central.
DR GO; GO:0019432; P:triglyceride biosynthetic process; IBA:GO_Central.
DR CDD; cd07993; LPLAT_DHAPAT-like; 1.
DR InterPro; IPR022284; GPAT/DHAPAT.
DR InterPro; IPR045520; GPAT/DHAPAT_C.
DR InterPro; IPR041728; GPAT/DHAPAT_LPLAT.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR PANTHER; PTHR12563:SF17; DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE; 1.
DR PANTHER; PTHR12563; GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE; 1.
DR Pfam; PF01553; Acyltransferase; 1.
DR Pfam; PF19277; GPAT_C; 1.
DR SMART; SM00563; PlsC; 1.
DR SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:CAJ07816.1}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAJ07816.1}.
FT DOMAIN 791..922
FT /note="Phospholipid/glycerol acyltransferase"
FT /evidence="ECO:0000259|SMART:SM00563"
SQ SEQUENCE 1436 AA; 155328 MW; 94F79C05CB2A6DB0 CRC64;
MSFPPPRLAL PEECKQVVLV APIDGFTAAC ACAIATSPLV PLNCRVLVDG IAVKSSSPSS
GNDSPHMACS SAESAATARD FMNTVQRVEA KLRASRATRR DVSVTHITQF YYGGVSPKAE
EIGPMLHRIH LLGSGALGET NFTASSTDVT AGSGGSSGVP RVADSVFVLV LSAQSLSPDT
ESGLKAYDIL LRRLWSAAGP SQAAETASQQ TRVRGSLVIL ADDVYRTAAC AMLSSIAKEV
ATAVDWVVLL AYAYAMDPPA LEFGATEVAV QAASGISLGG TLPVLCAANA LGVLRHFPVS
RGEPATITPV DVALNAALLG YVWLCHGELP ECVECAAEMQ YCGLSPAPSH AAAAAETATA
MPTQPAQCVT RHRMGSFAVA ESRKPGEVSL VWGMVGEYLM SYYGRFADQI SAAFPVAGVL
TQAPILQFPF SVADWVNFGP EPRAAAYALE GWRAYQQRQR LMEEKVGNAE AAQALKAYVA
QMDSVVRYIE RTARAAAARD KISAAFAASR RRTASSSFSV PPYRLDDFNV ALYHSLLRRL
TSHHTLMPYH QCVALVEVDW EAYVSVIARA VLEHLARCVL RSSSGLQHVR SRFHALPVAD
SANIGSVVRS PPVVSAPDEL APASAAVPSS TKPEAAASAA EAPFAFPEPR RYFTNDFVYR
GAERIPPFPS LLHKYFDCFV FLHRVGMTAN GWRGDMTPGM TPQVLTSIIA QPNIQRLMTA
LAAKDGASKK DVEARAKRLL LECGDALNHV HCRTLGLMIR TIFHSIYGRV DVNNGSYERL
HRYFAMPRVA VVFAPLHRSY IDFLILSEVL ALMRLPLPHI VAGENFLSMG VLATLMRGSG
ALFMRRSFRD DPLYAALLKE YVRHLVRARR PLEFFIEGAR SRTGKTMAPK LGLLKFVCDT
FYEPGQQELD DVLIVPVSLS YDEVLEATTH AKELLGVPKP KENPTNMLKA RSLLERMHGN
IHIHVGEPVS LRSLKQHPRQ CPLPLQPKDE QLRDPAAPAA ATTSVCKTLD TTPSIAKGSS
ITPIPLLGTV AWHLVYKLQR NTVITPASMV AAVVECLGPY YCTATTMLKE GIDTTAAAPT
AAAAMPLEKV HQGVEWLRGR LRERGAQLSA EASKLNPAGV VTLALTNLYR YIHITDEMSG
VTYHPDNVVT RLAVNISTNQ LIHVCMNEAL VAVVAQAFGF VTTPHRPPSG ADGAMLCGVR
SVKADVLSNQ TQLLQRLLSA EFPNYAEAAP VSFASWLECT VSQLQQCVEE HTVSSQLSGA
DTHGGTIVHL PVTQYYYFLL QLICPHVEAL YTVLAAASAL LAAYPGKPFG AAEVVTATQR
ACYILYAERK LRYIVAANKE TLQHYYESLI ALSLLQIKRV PITTTPGQSK VNGGVVAYTV
GLLGQEAALA RLEVLSTQIK ALWWHPSAAE GVTIDKAAIQ ERVLAVYREL TQPSKM
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