ID Q4Q459_LEIMA Unreviewed; 645 AA.
AC Q4Q459;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Putative ABC transporter {ECO:0000313|EMBL:CAJ06312.1};
GN ORFNames=LMJF_33_1300 {ECO:0000313|EMBL:CAJ06312.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ06312.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ06312.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ06312.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC kinase family. {ECO:0000256|ARBA:ARBA00009670}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR796429; CAJ06312.1; -; Genomic_DNA.
DR RefSeq; XP_001685889.1; XM_001685837.1.
DR AlphaFoldDB; Q4Q459; -.
DR STRING; 5664.Q4Q459; -.
DR EnsemblProtists; CAJ06312; CAJ06312; LMJF_33_1300.
DR GeneID; 5654543; -.
DR KEGG; lma:LMJF_33_1300; -.
DR VEuPathDB; TriTrypDB:LmjF.33.1300; -.
DR VEuPathDB; TriTrypDB:LMJFC_330023000; -.
DR VEuPathDB; TriTrypDB:LMJLV39_330020800; -.
DR VEuPathDB; TriTrypDB:LMJSD75_330020500; -.
DR eggNOG; KOG1235; Eukaryota.
DR HOGENOM; CLU_424831_0_0_1; -.
DR InParanoid; Q4Q459; -.
DR OMA; DVMTTMV; -.
DR Proteomes; UP000000542; Chromosome 33.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR CDD; cd13969; ADCK1-like; 1.
DR InterPro; IPR004147; ABC1_dom.
DR InterPro; IPR045307; ADCK1_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR43173:SF43; AARF DOMAIN-CONTAINING KINASE 5; 1.
DR PANTHER; PTHR43173; ABC1 FAMILY PROTEIN; 1.
DR Pfam; PF03109; ABC1; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 113..390
FT /note="ABC1 atypical kinase-like"
FT /evidence="ECO:0000259|Pfam:PF03109"
SQ SEQUENCE 645 AA; 72452 MW; 254831ACFBAF9009 CRC64;
MALLSSKAAR KWGRRCLYAT GILGVGYVGA DYVTDNSLTR SLRTLLAFGI IVYTYKLTTP
TTPEELSSMH SRVARIILDT CLKNEGLYIK IGQGLNSMSH VLPREYTEVL KVLLDRAPPV
PIAEIRKIIR AETGKEIEEL FVRFDETPVA SASIAQVHQA WLPPPADGAS AEPQRVAVKV
RKPCISTQSV WDLCIYSTIM TLLKLLFDLP TDWSRKTVCD ALVREMDFTL EASNAKRFRR
AFRDNPRLYI PRVHDAYTSK QLLVLEWIEG TKLNDVESIR AQYNEKRVLT TLFDAVGDMV
FKHGFVHADP HAANVLVRPL PKANPAPETA GTDMAAATTT TTTTAARDSS DYQVVLIDFG
LVTPERVRFR YQYALLFVSL FTHDKESLRR VVHDWGINDA EMFASIQAQK PFEAIQAGSY
DEVTRDEVIA MQTKAHERVK EILRDTRRIP KELIMVGRSL DILRSVNRLY GSPVNRMNMF
VQSAVECLGP LRNYDAVDAY LKRMQKIMEA RGCLTTVAMD CYQEYESVYD ASADTVREEQ
EAAAAQIAAE DAQRGLHHPL QGPASEVYAW LDAVYRALLL HSLLFLLNAV HVITYTYNSL
IATFLSAAAQ KKLRIASLED RRDPLLGQQW SIEGKEMAEA VLAAG
//
