ID Q4Q635_LEIMA Unreviewed; 654 AA.
AC Q4Q635;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Putative aminopeptidase {ECO:0000313|EMBL:CAJ08415.1};
GN ORFNames=LMJF_31_2260 {ECO:0000313|EMBL:CAJ08415.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ08415.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ08415.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ08415.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796427; CAJ08415.1; -; Genomic_DNA.
DR RefSeq; XP_001685213.1; XM_001685161.1.
DR AlphaFoldDB; Q4Q635; -.
DR STRING; 5664.Q4Q635; -.
DR EnsemblProtists; CAJ08415; CAJ08415; LMJF_31_2260.
DR GeneID; 5654158; -.
DR KEGG; lma:LMJF_31_2260; -.
DR VEuPathDB; TriTrypDB:LmjF.31.2260; -.
DR VEuPathDB; TriTrypDB:LMJFC_310037100; -.
DR VEuPathDB; TriTrypDB:LMJLV39_310031900; -.
DR VEuPathDB; TriTrypDB:LMJSD75_310031900; -.
DR eggNOG; ENOG502RXA8; Eukaryota.
DR HOGENOM; CLU_421250_0_0_1; -.
DR InParanoid; Q4Q635; -.
DR OMA; EHHCSII; -.
DR Proteomes; UP000000542; Chromosome 31.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0043171; P:peptide catabolic process; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR PANTHER; PTHR11533:SF174; PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Aminopeptidase {ECO:0000313|EMBL:CAJ08415.1};
KW Hydrolase {ECO:0000313|EMBL:CAJ08415.1};
KW Protease {ECO:0000313|EMBL:CAJ08415.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 234..343
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT DOMAIN 420..611
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT REGION 84..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 69944 MW; 58659EB496CAD334 CRC64;
MPSHRHNSPV VVAAEMRGQD FCAAALLDCV CFHMDRSTHI WNPIQCTLQL VFSRPSSGAA
IRAGSAYHGT SIIRYRREPY RDTADSAAGA ASSGATSPSE GNSEYEDFLR HRRVIAEKNA
LHLHALTTAG GMYKDVRVLD IQSYQVRCVS ASVDTAAAVL KIVSVEQEDA CAASADSSTG
GGAAKRKGSS KVRKKGGAAV VEHDDQTSGD SPATAAVDWG SKLILFEGSG SLPPLSEVDL
TSQFIGRVQS FDCGGIYAAC GIGSNPGTED VPLLTHFEVR FARCAFPAPD DPQYRLDWQL
KSIQVPSSFR TILTNGEERG RKKLAAQQAV QVSFSPCGPL PAYVFSFACF PGLAKLESTS
AADDGLEVVE GSVDIPKFAG GIASGLSDTS NLSYTLVPVR VLARRQARIA TATLERVLRL
TIEAVTALQQ LFQCPLPLLQ CEHLDVLLGP TMPYISGMEH HCSIILNEAI YQPGKKTAAA
GGGTAHRTAE VEQTELIVHE LTHHWVGNAL GLPFAVKEGI CQVIEQCLGD KLLGKPMRTY
KADSSASTKP ESSSPSSSTA TLPKSAIRAS EKGREFTGTS YQHALRAIKQ LVAAHGFDRF
AACLRQLMHV HVVLPAIAVE EGGGLQVLRC IRSDVASPPY LSTEQFLRTV ESAL
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