ID Q4Q6I0_LEIMA Unreviewed; 308 AA.
AC Q4Q6I0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Putative lipase {ECO:0000313|EMBL:CAJ08270.1};
DE EC=3.1.1.3 {ECO:0000313|EMBL:CAJ08270.1};
GN ORFNames=LMJF_31_0830 {ECO:0000313|EMBL:CAJ08270.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ08270.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ08270.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ08270.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796427; CAJ08270.1; -; Genomic_DNA.
DR RefSeq; XP_001685068.1; XM_001685016.1.
DR AlphaFoldDB; Q4Q6I0; -.
DR ESTHER; leima-P883.01; Lipase_3.
DR EnsemblProtists; CAJ08270; CAJ08270; LMJF_31_0830.
DR GeneID; 5654011; -.
DR KEGG; lma:LMJF_31_0830; -.
DR VEuPathDB; TriTrypDB:LmjF.31.0830; -.
DR VEuPathDB; TriTrypDB:LMJFC_310015400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_310014100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_310013800; -.
DR eggNOG; KOG4569; Eukaryota.
DR HOGENOM; CLU_032957_5_0_1; -.
DR InParanoid; Q4Q6I0; -.
DR OMA; CNANPSF; -.
DR Proteomes; UP000000542; Chromosome 31.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00519; Lipase_3; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002921; Fungal_lipase-like.
DR PANTHER; PTHR45856; ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN; 1.
DR PANTHER; PTHR45856:SF22; PUTATIVE-RELATED; 1.
DR Pfam; PF01764; Lipase_3; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CAJ08270.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..308
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004242084"
FT DOMAIN 96..238
FT /note="Fungal lipase-like"
FT /evidence="ECO:0000259|Pfam:PF01764"
SQ SEQUENCE 308 AA; 33063 MW; 4650DC7708E4B8E1 CRC64;
MLPSSCSRIV VVAALLLLCG GARAVVLSGE YSQTDAIRSL QYANATYADS DAVASWNCGG
SCNANPSFKV TSIVKGDDAH SLHAYVGVDE GSAQVVVALR GSATQQEQLM RQLVEPVLYD
ITSGCGLECR VHAGFQRSYL AVRRTIRAAV VRDLMMHPDY NVLVTGHSVG GAVALLAAID
VQAHVNRMFF VSRPIVSLYT FGMPHVGNRA FAVWAAGMLS RGSHFRITSR HDPVPRMLSS
GSADFQHVPY EVYCSAADGT NCRVCEGSVD SDDPTCIAHT SNVNMRDHFF YFGERISGGA
AGDAMLYL
//
