ID Q4Q797_LEIMA Unreviewed; 341 AA.
AC Q4Q797;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 89.
DE RecName: Full=C2H2-type domain-containing protein {ECO:0000259|SMART:SM00355};
GN ORFNames=LMJF_30_1980 {ECO:0000313|EMBL:CAJ06380.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ06380.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ06380.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ06380.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the ZNF277 family.
CC {ECO:0000256|ARBA:ARBA00034119}.
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DR EMBL; FR796426; CAJ06380.1; -; Genomic_DNA.
DR RefSeq; XP_001684801.1; XM_001684749.1.
DR AlphaFoldDB; Q4Q797; -.
DR EnsemblProtists; CAJ06380; CAJ06380; LMJF_30_1980.
DR GeneID; 5653740; -.
DR KEGG; lma:LMJF_30_1980; -.
DR VEuPathDB; TriTrypDB:LmjF.30.1980; -.
DR VEuPathDB; TriTrypDB:LMJFC_300029400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_300026300; -.
DR VEuPathDB; TriTrypDB:LMJSD75_300026100; -.
DR eggNOG; KOG2482; Eukaryota.
DR HOGENOM; CLU_814968_0_0_1; -.
DR InParanoid; Q4Q797; -.
DR OMA; DFPMVPT; -.
DR Proteomes; UP000000542; Chromosome 30.
DR InterPro; IPR041661; ZN622/Rei1/Reh1_Znf-C2H2.
DR InterPro; IPR040048; ZNF277.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR13267; ZINC FINGER PROTEIN 277; 1.
DR PANTHER; PTHR13267:SF3; ZINC FINGER PROTEIN 277; 1.
DR Pfam; PF12756; zf-C2H2_2; 2.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 24..47
FT /note="C2H2-type"
FT /evidence="ECO:0000259|SMART:SM00355"
FT DOMAIN 81..107
FT /note="C2H2-type"
FT /evidence="ECO:0000259|SMART:SM00355"
FT DOMAIN 188..207
FT /note="C2H2-type"
FT /evidence="ECO:0000259|SMART:SM00355"
FT REGION 144..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 341 AA; 37813 MW; EBE2BE44BFDFFBF7 CRC64;
MAEGLKESCK KILQRLQQQD VEEFGCILCS QHVRGQDALM QHLITEHQVH CLHFDNVVDL
PGLLEHLSTL LHSHVTSPAQ WFCPVCGEDT ASDSAETLVR HMRLAGHQHW NPHTIPSMAP
WCVTGISAPT GPSDKVLAAT AMPATCAPSS PAPQGLGRGD ADEETTDSEW KDIEDEEVDE
DEDWNLECVC LYCDYSGEDV LQHLRTHHNF DFRASVLRRP DLHDEYDLIR VVNMVRRAVC
SDRCPYGDEC DVDGKQNNRA ALEAHLALHK EHRLPRRVST SDADLIPVLP GDAFISMLVT
SGEGFLQTEE EDPDFPMVPT VQELAAAASR APQTAKSLAS T
//
