ID Q4Q7B0_LEIMA Unreviewed; 1374 AA.
AC Q4Q7B0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=Putative phosphatidylinositol kinase {ECO:0000313|EMBL:CAJ06343.1};
DE EC=2.7.1.137 {ECO:0000313|EMBL:CAJ06343.1};
GN ORFNames=LMJF_30_1850 {ECO:0000313|EMBL:CAJ06343.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ06343.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ06343.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ06343.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796426; CAJ06343.1; -; Genomic_DNA.
DR RefSeq; XP_001684788.1; XM_001684736.1.
DR STRING; 5664.Q4Q7B0; -.
DR EnsemblProtists; CAJ06343; CAJ06343; LMJF_30_1850.
DR GeneID; 5653727; -.
DR KEGG; lma:LMJF_30_1850; -.
DR VEuPathDB; TriTrypDB:LmjF.30.1850; -.
DR VEuPathDB; TriTrypDB:LMJFC_300028000; -.
DR VEuPathDB; TriTrypDB:LMJLV39_300024800; -.
DR VEuPathDB; TriTrypDB:LMJSD75_300024600; -.
DR eggNOG; KOG0906; Eukaryota.
DR HOGENOM; CLU_256098_0_0_1; -.
DR InParanoid; Q4Q7B0; -.
DR OMA; ELCISEY; -.
DR Proteomes; UP000000542; Chromosome 30.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR GO; GO:0034271; C:phosphatidylinositol 3-kinase complex, class III, type I; IBA:GO_Central.
DR GO; GO:0034272; C:phosphatidylinositol 3-kinase complex, class III, type II; IBA:GO_Central.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10048:SF120; 3-KINASE CATALYTIC SUBUNIT, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CAJ06343.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transferase {ECO:0000313|EMBL:CAJ06343.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 457..530
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1374 AA; 147784 MW; 21098D40144814D7 CRC64;
MSDAPAATAA AEAATTARTE NPVAVCPATP PPTNCIGSVW LGVYDRVSHT RFRIHIEDPV
FLCIVSNTVV PAAESDGSLP FEMQEFVECL DAYERERLRQ AYAARRGTNT SGGGVGIGRC
GVHGDPAAAA ATAGSCGAGG AVSGSGAIHS GVFGIPPMCC LNSCSPAGGP VPRKLEETLR
ETLSENSDFF FRVSSVAYHL DPNPQGASAC TPASASVGSG VMGNAGVGAC SPRRGEGLAS
AAAGGVASLL SNTIAAASAT GPPPRRKYSV HSGYSAAFHL CGRLFADVYR DHCRALAQKI
ASGFSGLRVE DCVKFRKAVW SGFHLKALEP YRSGARSESN LELRWVSEKI KDDQHLFPSR
GVAPQQESSH VSRLVDATLS YVANARLRGR PSSSIGGNAN SSTGGNGAAG AGGAGAAGKG
GGSAAARATV GGVAEENELN TFGLTKLLHN PSWQKDDESS DSCPSCGRAF ISLSRPLGTR
AHHCRSCGIR LCVFCITRRA HYSFAKLAKP GSSDEAEERL VCDTCYKEYE TVSQLHYLGA
LFAFAGLGFS DLVLCRTVNE QWREAAELCI SEYRLLLHNC DANLHSVKTP VGILLQNSLF
LLLGDGPTSS IPVVHHPEAA LLLLKFIATE NLWVPDASYY FIWRLSSSVL NRADTVLTSL
PSLSSSAASA VESKHHSFQL PVVPNFSHWH LFCTAFCSKI GSSYFFVKCA ELLCAAPAKV
YDAYVASALE RMTRVYLSTT PLWKRLAEAN QATAAAFAAR TSSPPTTAPL PLPMLSDVTE
GQVVTVWLLD MLHKDALVPA QRRRFQQLLE HVIPTVAGSS LSLVFIMLLS LQSTYSYYGY
DEDLFGLWRT RIVAEVGRKD PVARDRVVAT LDFFHELDGF CAQSSVVSQT SVVGWIVAYC
RRGAPKAPAS ATGAPGEATM PSARRVYHHS YIDLPHPILN PFKPYIVLKS IRLSGVKVAP
NAASKPTWLA FSTWSAAEHL ERDTTTAAEN FGRHTLPTGE SHAERSGEGR EKGTGAASTY
LSTKTSAPVT RPVTAVNGVS PEALHESLPQ EYMFLYKREN VERDQLMCIS SRLLQMLLSS
EIGNAEMLDY SVLPLSCDSG LIEKAEGREL SNLDNMDIAS YVLHRGTRSC INFLASAKLF
LLLNYIFSIG DRHKGNVLIG TNGALLHIDF RFIFSEKTFV EKLARSTVRI DDAFLAAVEQ
CQQRQCSCFA GSSPAATSSH AQGWASPPAS SGSGGRGSCA SPTKAPEPSS AEIREAFFSS
AAEWFVHVRP FAAVFYELWL YAVHRHTVPY NDAEMLNMLN TLFDRHASQT SSASKFSTTM
KESVNVCRLK DVTHSSAEVL RTFADQVSRR VSESSVDAMK MMGSMWSSWW SRGG
//