ID Q4Q7P9_LEIMA Unreviewed; 472 AA.
AC Q4Q7P9;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE SubName: Full=Putative spliceosome-associated protein {ECO:0000313|EMBL:CAJ05935.1};
GN ORFNames=LMJF_30_0570 {ECO:0000313|EMBL:CAJ05935.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ05935.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ05935.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ05935.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796426; CAJ05935.1; -; Genomic_DNA.
DR RefSeq; XP_001684647.1; XM_001684595.1.
DR AlphaFoldDB; Q4Q7P9; -.
DR STRING; 5664.Q4Q7P9; -.
DR EnsemblProtists; CAJ05935; CAJ05935; LMJF_30_0570.
DR GeneID; 5653582; -.
DR KEGG; lma:LMJF_30_0570; -.
DR VEuPathDB; TriTrypDB:LmjF.30.0570; -.
DR VEuPathDB; TriTrypDB:LMJFC_300011700; -.
DR VEuPathDB; TriTrypDB:LMJLV39_300011200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_300011000; -.
DR eggNOG; KOG2330; Eukaryota.
DR HOGENOM; CLU_046067_0_0_1; -.
DR InParanoid; Q4Q7P9; -.
DR OMA; QWGEPPR; -.
DR Proteomes; UP000000542; Chromosome 30.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR007180; DUF382.
DR InterPro; IPR006568; PSP_pro-rich.
DR PANTHER; PTHR12785; SPLICING FACTOR 3B; 1.
DR PANTHER; PTHR12785:SF6; SPLICING FACTOR 3B SUBUNIT 2; 1.
DR Pfam; PF04037; DUF382; 1.
DR Pfam; PF04046; PSP; 1.
DR SMART; SM00581; PSP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 262..316
FT /note="PSP proline-rich"
FT /evidence="ECO:0000259|SMART:SM00581"
FT REGION 91..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..28
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 56..91
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 373..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 51233 MW; B6DEC7C4BC1C24BA CRC64;
MAKSKKEKKA ARREREAQLK KISQKIQEKI LLAEVATAEG EVEEIVYTLP PTPAELRAAE
EEQERQKAAI AAEAEERAAA AAAEVVQAAA AASAEKDEED RVVLPSLDGG EGNAKGRRHS
SVLSGRKHHR MTWEELKLRA AEMYGLEATE LVDQHDGNAV DPLFTVRMKM EPHTVPVPHH
WHLQRTFLSR QADREEAVGI VPAEVAALGI EKIRATKDKM ANPNQVAFIS CFMTGTPLQC
KTYNVELSRC GDVFYEGKWR PKAHHTPGVL SKRLRQALGI GPTAPPPWLY SMQTMRRLPP
AYPDLRIPGL NAPIPAGGQW GLGQDQWGEP PRAEDNSFLF PGVMDEAAAA GSTQAELRWG
TVPPLVTSHE EAPSVAGASS SGAASPAPAT AAQALQRPTP AAGRPVITPV PFQPQAYVLQ
QAVPAARVTP QEYVQVQDNT TNSTVAVGYM MMPKDGVQSQ PPLSRYPRPQ GS
//
