ID Q4Q974_LEIMA Unreviewed; 646 AA.
AC Q4Q974;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 99.
DE RecName: Full=J domain-containing protein {ECO:0000259|PROSITE:PS50076};
GN ORFNames=LMJF_26_1200 {ECO:0000313|EMBL:CAJ05168.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ05168.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ05168.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ05168.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796422; CAJ05168.1; -; Genomic_DNA.
DR RefSeq; XP_001684124.1; XM_001684072.1.
DR AlphaFoldDB; Q4Q974; -.
DR STRING; 5664.Q4Q974; -.
DR EnsemblProtists; CAJ05168; CAJ05168; LMJF_26_1200.
DR GeneID; 5652848; -.
DR KEGG; lma:LMJF_26_1200; -.
DR VEuPathDB; TriTrypDB:LmjF.26.1200; -.
DR VEuPathDB; TriTrypDB:LMJFC_260018300; -.
DR VEuPathDB; TriTrypDB:LMJLV39_260017700; -.
DR VEuPathDB; TriTrypDB:LMJSD75_260016100; -.
DR eggNOG; KOG0691; Eukaryota.
DR HOGENOM; CLU_498345_0_0_1; -.
DR InParanoid; Q4Q974; -.
DR OMA; PLYYCVN; -.
DR Proteomes; UP000000542; Chromosome 26.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR PANTHER; PTHR44094; DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44094:SF7; PROTEIN DNAJ, PUTATIVE-RELATED; 1.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 282..346
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 251..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..268
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 71126 MW; B1317886BA7185F0 CRC64;
MSRFTIRRFV LQNIIAVAAR CPSATVASAA VAVMTGGTGP ASASAASSSS TGSWVRRMLV
KSRAGSTSAF SSHFALVTEA EMERIRRCRR EDAEESRVVL ATCPSRSVLR GIGGGALNVV
LGFVISPLVL LAVSLERVRL GSGVSALWTA PCYGLLWGGV FLVCAQYAAV QQVALSSYYS
CVATPLYYCV NRRPMADVAA SASTSAPRAR AWTWNGLRCC FEAPQGTPNA HHPLLQLYED
PSVLRERAMK RVTRRDKDRI KRKAKYSGKA KTGGTDGVAD DDYYGLLGVP TDATPRQIKE
AYNTKVLHIH PDRNPSPDAA RQFDRVTKAY RVLSSPQKRK KFDLGGTEGV EDTGARKRDA
VRALFGGEEV HRIAGDVFMS SFSQRVIDGL DYTGEELAVL RQRMYEQCRD ELLCNYLVHY
DAAAAASKKV ADEKKRSGSC RGPWKGDALT IRLRNILSTG LAKEVLHTIG HEYKRVIAYF
DMERRRPSGS GEAGEANGGA LPSPVRDAVA PHSKSVSLPF LVVARAKLYF KTVGPHRWQV
RRQKFTYLAA VRGRTFKDSE AMVDLAWYTS VQELEATANT VALALLYDPQ LPAAEAARRR
DALEALADTF ILYGQPYKGA NKSTMNQLMN SMREYQQQRQ REKDTQ
//
